皇家华人

皇家华人
皇家华人 Cancer Center

Biostatistics Shared Resource (BSSR)

Biostatistics Shared Resource services cover the spectrum of cancer-related research activities, including: experimental design, sample size calculation, randomization, analysis plans, data analysis, grant and manuscript preparation, full clinical trial support, and innovative targeted methods development.

Scheduling, Location, and Hours of Operation

Medical Educational Building, Biostatistics suite | Monday–Friday from 8 a.m.-5 p.m.
For support, please email the BSSR Director, Paul L. Auer at pauer@mcw.edu.

Services and Technologies

The major categories of service provided by BSSR include grant development, collaboration, consultation, clinical trial support, and manuscript preparation.

View the FY25 BSSR price sheet (PDF)

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Grant Development
Provides support in preclinical, animal, and observational study design, including sample size determination, randomization, analysis plans, and grant preparation.
  • Preliminary data analysis including sample size determination, randomization, and analysis plans
  • Study design and development of statistical analysis plans for preclinical, animal and observational studies
  • Hypothesis development
Collaboration
  • Attendance at Program and transdisciplinary team meetings
  • Developing databases for data capture and management
  • Mentoring junior investigators
Consultation

Provides cancer-related data analysis, including image and spatial datasets, survival analysis, measurement error, machine learning, and genomics.

  • Power and sample size calculations
  • Cancer-related data analysis and interpretation of results including image and spatial datasets, survival analysis, measurement error, machine learning, and genomics
  • Preparing data summaries for abstracts and manuscripts
Clinical Trial Development, Monitoring, and Analysis
Provides data analytics of investigator-initiated trials, including novel trial methodology development, standard protocol design and development, case report form review, safety monitoring and reporting to the Data and Safety Monitoring Committee, for all phases of clinical trials.
  • Comprehensive support for trials from development of the protocol and statistical analysis plan through implementation, monitoring, analysis and preparation of final reports and manuscripts
  • BSSR faculty develop trial design (e.g., Bayesian adaptive designs and dose-finding trials) and advocate for trials that maximize efficiency while addressing the trial’s objectives, patient protection and confidentiality, and ethical considerations
  • Data analytics of investigator-initiated trials, including novel trial methodology development, standard protocol design and development, case report form review, safety monitoring and reporting to the Data and Safety Monitoring Committee, for all phases of clinical trials
Manuscript Preparation
Provides standard data analysis and development of innovative machine learning approaches for analyzing complex datasets, and reporting of results via presentations and scientific publication.
  • Standard data analysis and development of innovative machine learning approaches for analyzing complex datasets
  • Preparation of tables, figures and text for Methods
  • Help with interpretation of results including reporting of results via presentations and scientific publication. and reviewing the quantitative and statistical aspects of manuscripts
biostatistics

iLab Requests and Support

Access the links below to learn how to register for iLab and submit requests.

 

Researcher at Monitor

Shared Resource Acknowledgement

A condition for using MCW Cancer Center supported Shared Resources is that each Shared Resource is acknowledged in the publication. These acknowledgements enable the Cancer Center to measure and document Shared Resource productivity, impact, and service to members.

View Shared Resource acknowledgement instructions. (PDF)

Leadership

headshot

Paul Auer, PhD

Director, Biostatistics Shared Resource (BSSR)

pauer@mcw.edu

View Profile

Notable Publications

(Levis MJ, Hamadani M, Logan B, Jones RJ, Singh AK, Litzow M, Wingard JR, Papadopoulos EB, Perl AE, Soiffer RJ, Ustun C, Ueda Oshima M, Uy GL, Waller EK, Vasu S, Solh M, Mishra A, Muffly L, Kim HJ, Mikesch JH, Najima Y, Onozawa M, Thomson K, Nagler A, Wei AH, Marcucci G, Geller NL, Hasabou N, Delgado D, Rosales M, Hill J, Gill SC, Nuthethi R, King D, Wittsack H, Mendizabal A, Devine SM, Horowitz MM, Chen YB, BMT-CTN 1506/MORPHO Study Investigators) J Clin Oncol 2024 May 20;42(15):1766-1775. PMID: 38471061; PMCID: PMC11095884; DOI: 10.1200/JCO.23.02474; Scopus ID: 2-s2.0-85193456124

(Buradagunta CS, Arsang-Jang S, Massat B, Thapa B, Patek V, D'Souza A, Auer P, Urrutia R, Janz S, Dhakal B, Hari P, Dong J) Leukemia 2024 Feb;38(2):383-385. PMID: 37919604; DOI: 10.1038/s41375-023-02078-6; Scopus ID: 2-s2.0-85175540732

 (Auer PL, Wang G, Li G, DeWan AT, Leal SM) BMC Genomics 2023 Jun 06;24(1):303. PMID: 37277705; PMCID: PMC10242917; DOI: 10.1186/s12864-023-09415-0; Scopus ID: 2-s2.0-85160972672

 (Sparapani RA, Logan BR, Maiers MJ, Laud PW, McCulloch RE) Biometrics 2023 Dec;79(4):3023-3037. PMID: 36932826; PMCID: PMC10505620; DOI: 10.1111/biom.13857; Scopus ID: 2-s2.0-85153305626  

 (Nakamura R, Saber W, Martens MJ, Ramirez A, Scott B, Oran B, Leifer E, Tamari R, Mishra A, Maziarz RT, McGuirk J, Westervelt P, Vasu S, Patnaik M, Kamble R, Forman SJ, Sekeres MA, Appelbaum F, Mendizabal A, Logan B, Horowitz M, Cutler C) J Clin Oncol 2021 Oct 20;39(30):3328-3339. PMID: 34106753; PMCID: PMC8791814; DOI: 10.1200/JCO.20.03380; Scopus ID: 2-s2.0-85112086284

 (Shaw BE, Jimenez-Jimenez AM, Burns LJ, Logan BR, Khimani F, Shaffer BC, Shah NN, Mussetter A, Tang XY, McCarty JM, Alavi A, Farhadfar N, Jamieson K, Hardy NM, Choe H, Ambinder RF, Anasetti C, Perales MA, Spellman SR, Howard A, Komanduri KV, Luznik L, Norkin M, Pidala JA, Ratanatharathorn V, Confer DL, Devine SM, Horowitz MM, Bolaños-Meade J) J Clin Oncol 2021 Jun 20;39(18):1971-1982. PMID: 33905264; PMCID: PMC8260905; DOI: 10.1200/JCO.20.03502; Scopus ID: 2-s2.0-85108386444

(Fuchs EJ, O'Donnell PV, Eapen M, Logan B, Antin JH, Dawson P, Devine S, Horowitz MM, Horwitz ME, Karanes C, Leifer E, Magenau JM, McGuirk JP, Morris LE, Rezvani AR, Jones RJ, Brunstein CG) Blood 2021 Jan 21;137(3):420-428. PMID: 33475736; PMCID: PMC7819761; DOI: 10.1182/blood.2020007535; Scopus ID: 2-s2.0-85092507677

 (Shah NN, Johnson BD, Schneider D, Zhu F, Szabo A, Keever-Taylor CA, Krueger W, Worden AA, Kadan MJ, Yim S, Cunningham A, Hamadani M, Fenske TS, Dropuli膰 B, Orentas R, Hari P) Nat Med 2020 Oct;26(10):1569-1575. PMID: 33020647; DOI: 10.1038/s41591-020-1081-3; Scopus ID: 2-s2.0-85092105030

 (Martens MJ, Logan BR) Lifetime Data Anal 2020 Jul;26(3):603-623. PMID: 31729633; PMCID: PMC7365590; DOI: 10.1007/s10985-019-09491-z; Scopus ID: 2-s2.0-85075483839

(Bemanian A, Cassidy LD, Fraser R, Laud PW, Saeian K, Beyer KMM) Cancer Causes Control 2019 Dec;30(12):1277-1282. PMID: 31531799; PMCID: PMC6858574; DOI: 10.1007/s10552-019-01232-9; Scopus ID: 2-s2.0-85073816952