皇家华人 Emergency Medicine Resuscitation Research Center
The Resuscitation Research Center (RRC) in the Department of Emergency Medicine department at the 皇家华人 is supported by federal funding to collaborate with researchers, clinicians and EMS at the local and national level on observational and interventional clinical trials in the areas of emergency resuscitation and neurological emergency research. The RRC has dedicated infrastructure to coordinate clinical trial activities 24/7.
The Resuscitation Research Center is also a regional site for four NIH funded research networks: the Resuscitation Outcomes Consortium (ROC), the Neurological Emergencies Treatment Trials Network NETT), Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) and the Early Phase Pain Investigation Clinical Network (EPPIC-Net).
Listen to on WUWM's Lake Effect NPR (National Public Radio) interview where he discusses how a collaborative partnership between the 皇家华人 and Milwaukee County EMS has improved prehospital medical care and outcomes in Southeastern Wisconsin.
BOOST-3 Trial (Ongoing)
BOOST-3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Learn more on the .
BOOST-3 Opt-Out
We respect the wishes of any member of our community who does not wish to be enrolled in an Exception from Informed Consent research study being conducted at Froedtert Hospital. In order to opt-out of this study, you can request an opt-out bracelet or necklace free of charge. To obtain an opt-out bracelet or necklace, you can either call the Resuscitation Research Center at (414) 805-6493 or email us at RRC@mcw.edu. Your bracelet or necklace will be immediately shipped to you free of charge to the specified address.
ACCESS Trial (Completed)
Access to the cardiac catheterization laboratory in patients without ST-segment elevation myocardial infarction resuscitated from out-of-hospital ventricular fibrillation cardiac arrest (ACCESS) Find study results on the ACCESS Trial page.
Resuscitation Outcomes Consortium (ROC) (Completed)
What is ROC?
The Resuscitation Outcomes Consortium (ROC) is a clinical research network consisting of 10 Regional Clinical Centers throughout the United States and Canada, as well as a Data Coordinating Center. It was created to study better ways to treat people that have an out-of-hospital cardiac arrest or a severe traumatic injury.
Why is ROC research important?
Cardiac arrest and traumatic injury are important public health problems. Heart disease is the most common cause of death in North America. Over 350,000 out-of-hospital cardiac arrests occur each year in the United States. Of those, less than 10% survive. Life-threatening severe injury is the leading cause of death in North America for persons between the ages of 1 and 44 years, and one of the leading causes of death in those over the age of 65 years.
ROC Brochure (English) (PDF) | ROC Brochure (Spanish) (PDF)
ROC Opt-Out
We respect the wishes of any member of our community who does not wish to be enrolled in an Exception from Informed Consent research study being conducted with Milwaukee County EMS Providers (MCEMS) and Flight for Life. In order to opt-out of these studies, you can request an opt-out bracelet or necklace (shown below) free of charge. This bracelet or necklace applies to all of our studies currently being conducted by Milwaukee County EMS and Flight for Life. MCEMS and Flight for Life providers are trained to NOT enroll citizens wearing this bracelet or necklace in any research study. To obtain an opt-out bracelet or necklace, you can either call the Resuscitation Research Center at (414) 805-6493 or email us at RRC@mcw.edu. Your bracelet or necklace will be immediately shipped to you free of charge to the specified address.
ROC Clinical Trials at MCW (All ROC Trials Completed)
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ALPS
Amiodarone (PM101), Lidocaine, or Placebo for treatment of recurrent ventricular fibrillation or pulseless ventricular tachycardia in patients with out-of-hospital cardiac arrest.
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CCC
Continuous Chest Compressions (CCC) CPR versus Standard AHA 30:2 CPR in patients with out-of-hospital cardiac arrest.
learn more -
TXA
Prehospital Tranexamic Acid (TXA) use for treatment of patients with Traumatic Brain Injury (TBI).
learn more -
PART
Pragmatic trial of Airway Management in Out-of-Hospital Cardiac Arrest.
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Neurological Emergencies Treatment Trials Network (NETT) (All NETT Trials Completed)
What is NETT?
The NIH has created a to conduct large simple trials to reduce the burden of very acute injuries and illnesses affecting the brain, spinal cord, and peripheral nervous system. The network recognizes and seeks to explore the special narrow window of opportunity that seems to exist in treating neurologic damage from a variety of pathologies ranging from stroke to traumatic brain injury to seizures to meningitis. The study of very rapid interventions will have to be implemented by paramedics in the field, or by physicians in the Emergency Department. This network provides the basis for conducting efficient studies in these environments.
The mission of the Neurological Emergencies Treatment Trials (NETT) Network is to improve outcomes of patients with acute neurologic problems through innovative research focused on the emergent phase of patient care.
Exception From Informed Consent
The Resuscitation Research Center conducts some research studies under the Exception From Informed Consent Guidelines by the Food and Drug Administration. .
Per these federal regulations, the Resuscitation Research Center does the following for all Exception From Informed Consent studies:
- Conduct a Community Consultation (survey) of residents in the Milwaukee area to obtain their attitudes and opinions regarding whether this study should be completed in Milwaukee. The Institutional Review Board (IRB) at MCW, closely reviews these results to determine if the Milwaukee community approves of the study.
- Conduct public notification: Prior to the start of the study, notices are placed in several newspaper publications, radio announcements and web postings.
Public
Visit studies listed above for specific public notices. In addition, we provide a way for anyone who wishes not to be enrolled in studies being conducted with Milwaukee County EMS to opt-out. See the ROC Opt-Out information listed under the above Resuscitation Outcomes Consortium (ROC).
NETT Clinical Trials at MCW (All NETT Trials Completed)
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NETT POINT
Platelet-Oriented Inhibition in New TIA and Minor ischemic stroke (POINT) Trial
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NETT SHINE
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
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NETT ESETT
The Established Status Epilepticus Treatment Trial (ESETT)
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Resuscitation Research Center
I welcome your comments and questions.
Tom P. Aufderheide, MD, MS, FACEP, FACC, FAHA
皇家华人
Department of Emergency Medicine
Hub for Collaborative Medicine 鈥 3rd Floor
8701 Watertown Plank Rd.
Milwaukee, WI 53226
Cardiac Arrest FAQs (PDF) | Common Myths About Cardiac Arrest (PDF)
(414) 805-6493