皇家华人

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Research Bench Lab
Microbiology & Immunology

Dwinell Laboratory

Location
Microbiology & Immunology
TBRC C3860

General Interests
Cancer Progression and the Tumor Immune Microenvironment

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Michael Dwinell Laboratory
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Research Areas

My research has been investigating the cellular, biochemical, molecular and pathophysiologic mechanisms controlling cellular movement in inflammation and cancer. The movement of cells within and between tissues is a fundamental property of biology. Cell movement / migration, may have beneficial effects, for example in wound healing or leukocyte trafficking, or deleterious effects, such as in the invasion and metastasis of tumor cells. My laboratory uses a spectrum of cellular, molecular, metabolomic and biochemical techniques, in combination with an array of cell culture and preclinical transgenic mouse models, to dissect the details of how cells move and the functional consequences of that movement. As chemokines are the archetype immune molecules directing cell movement, the investigative focus of my research program is to resolve the mechanisms of chemokine signaling in order to improve human health through the design of new chemokine-targeted or immune targeted therapies to disrupt or promote cellular movement in inflammation and cancer.

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Dwinell Laboratory: Science Needs All of Us

Achieving important and productive science requires an inclusive team in which everyone is equal and mutually reinforcing the efforts of the entire group. The Dwinell laboratory continues to model and foster an equal, inclusive, diverse environment that respectfully promotes high quality science and excellent training. The Dwinell lab welcomes individuals from all groups and backgrounds to join our research team.

Research Support

Research in the Dwinell laboratory is supported through grants from the National Institutes of Health, long standing support from the Bobby Nick Voss Charitable Foundation, the 皇家华人 Cancer Center and philanthropic donations.

Current Members

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Kathleen Boyle, PhD

Adjunct Assistant Professor

kboyle@mcw.edu

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Donovan Drouillard

G3 Student

ddrouillard@mcw.edu

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Donna McAllister

Lab Supervisor, Dwinell Lab

dmcallis@mcw.edu

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Maria Poimenidou

Graduate Student

mpoimenidou@mcw.edu

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Elisabeth Solis

Graduate Student

esolis@mcw.edu

Recent Publications

  • (Roy I, Binder-Markey B, Willbanks A, Sychowski D, Phipps T, Barber A, McAllister D, D'Andrea D, Franz CK, Pichika R, Dwinell MB, Lieber RL.) J Appl Physiol (1985). 2024 Sep 01;137(3):705-717 PMID: 39052773 PMCID: PMC11424168 SCOPUS ID: 2-s2.0-85204163300 07/26/2024

  • (Drouillard D, Halyko M, Cinquegrani E, McAllister D, Peterson FC, Marchese A, Dwinell MB.) bioRxiv. 2024 Aug 27 PMID: 39253415 PMCID: PMC11383031 09/10/2024

  • (Roy I, Binder-Markey B, Sychowski D, Willbanks A, Phipps T, McAllister D, Bhakta A, Marquez E, D'Andrea D, Franz C, Pichika R, Dwinell MB, Jayabalan P, Lieber RL.) bioRxiv. 2023 Nov 15 PMID: 38014165 PMCID: PMC10680669 11/28/2023

  • (Keyes RF, McAllister D, Dwinell MB, Smith BC.) STAR Protoc. 2023 Sep 15;4(3):102437 PMID: 37552599 PMCID: PMC10424135 SCOPUS ID: 2-s2.0-85175638505 08/08/2023

  • (Mohan M, Janz S, Brazauskas R, Dwinell MB, Teng BQ, Yun G, Dong J, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, D'Souza A.) Bone Marrow Transplant. 2023 Aug;58(8):953-955 PMID: 37149674 PMCID: PMC10555486 SCOPUS ID: 2-s2.0-85158126520 05/07/2023

  • (Zhou AL, Jensen DR, Peterson FC, Thomas MA, Schlimgen RR, Dwinell MB, Smith BC, Volkman BF.) SLAS Discov. 2023 Jun;28(4):163-169 PMID: 36841432 PMCID: PMC10339762 SCOPUS ID: 2-s2.0-85149845436 02/26/2023

  • (Wu X, Clarke WR, Koplinski CA, Peterson FC, Dwinell MB, Wei G, Chao E, Huynh M, Yamada D, Volkman BF, Hwang ST.) J Immunol Methods. 2023 Apr;515:113453 PMID: 36863695 PMCID: PMC10715733 SCOPUS ID: 2-s2.0-85150034077 03/03/2023

  • (D'Souza A, Brazauskas R, Teng BQ, Yun G, Uttley H, Dong J, Dwinell MB, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, Janz S.) Bone Marrow Transplant. 2023 Mar;58(3):334-336 PMID: 36460820 SCOPUS ID: 2-s2.0-85143207078 12/03/2022

  • (Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, Blumer JB, Luttrell LM, McCorvy JD, Hill WD.) ACS Pharmacol Transl Sci. 2023 Jan 13;6(1):22-39 PMID: 36659961 PMCID: PMC9844133 01/21/2023

  • (Vonderhaar EP, Dwinell MB, Craig BT.) Front Immunol. 2023;14:1202169 PMID: 37426669 PMCID: PMC10325564 SCOPUS ID: 2-s2.0-85164152167 07/10/2023

  • (Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, Blumer JB, Luttrell LM, McCorvy JD, Hill WD.) ACS Pharmacology and Translational Science. 13 January 2023;6(1):22-39 SCOPUS ID: 2-s2.0-85143982229 01/13/2023

  • (Drouillard D, Craig BT, Dwinell MB.) Am J Physiol Cell Physiol. 2023 Jan 01;324(1):C167-C182 PMID: 36317799 PMCID: PMC9829481 SCOPUS ID: 2-s2.0-85145954846 11/02/2022

  • (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB.) iScience. 2022 Dec 22;25(12):105670 PMID: 36567718 PMCID: PMC9768319 12/27/2022

  • (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB.) iScience. 22 December 2022;25(12) SCOPUS ID: 2-s2.0-85143723525 12/22/2022

  • (Jørgensen AS, Brandum EP, Mikkelsen JM, Orfin KA, Boilesen DR, Egerod KL, Moussouras NA, Vilhardt F, Kalinski P, Basse P, Chen YH, Yang Z, Dwinell MB, Volkman BF, Veldkamp CT, Holst PJ, Lahl K, Goth CK, Rosenkilde MM, Hjortø GM.) Cell Mol Life Sci. 2021 Nov;78(21-22):6963-6978 PMID: 34586443 PMCID: PMC8558179 SCOPUS ID: 2-s2.0-85116031161 09/30/2021

Publications of from the

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Flashback

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2017

Wearing purple for World Pancreatic Cancer Day
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2013

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2010

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Lab Alumni

Hong Guan, MS

Doctoral Candidate, Department of Chemistry and Biochemistry, University of South Carolina

 

Ishan Roy, MD, PhD

Clinical Instructor & Chief Resident Physician; Department of Physical Medicine & Rehabilitation, Northwestern University/Shirley Ryan Ability Lab

 

Natasha Moussouras, PhD

Research Fellow, Department of Microbiology & Immunology, 皇家华人

 

Emily Vonderhaar, PhD

Clinical Research Training Fellow, Department of Microbiology & Immunology, 皇家华人

 

Jonathan D. Van Wickle

Resident, Radiation Oncology, University of Iowa

 

Eric A. Luedke, MD

General Surgery, Sharp Memorial Hospital, Stanford Health Care-Stanford Hospital, San Diego, CA.

 

Yana Thaker, MD

General Internal Medicine, Gastroenterology, University of Washington, Seattle, WA

 

Joanne P Boisvert (Hayes), MD

Family Medicine Practice, Madras, OR

 

Egal I. Gorse, MD

2018- Fellowship Hematology and Medical Oncology, Emory University School of Medicine 2020 Recipient Nell W. and William Simpson Elkin Fellowship

 

Kimberle A Agle. PhD

Scientist-II, Immucor, Inc, Waukesha, WI

 

Amanda N. Cooper, MD

Private Practice, Dermatology, Germantown, WI

 

Luke J. Drury, PhD

Human Molecular Geneticist, Prevention Genetics, Marshfield Clinic, Marshfield, WI

 

Sheena L. Faherty

Science Writer, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD

 

Soonyean Hwang, PhD

Postdoctoral Fellow, Dana-Farber Cancer Institute, Harvard Cancer Center, Mentor: Martin E. Hemler, PhD

 

Priscilla A. Johanesen, PhD

Associate Professor (Tenured), Deputy Head of Department (Education), Department of Microbiology, Monash University, Melbourne, AUSTRALIA

 

Jennifer M. Boardman (Smith), PhD

Assistant Dean for Academic Affairs for the School of Graduate Studies, Associate Professor, Microbiology and Immunology, Department of Basic Sciences, Geisinger

 

Rebecca A. Vongsa, PhD

Scientist-III, Kimberly-Clark Corp., Skin Health and Infection Control Health Care Division, Appleton, WI

 

Michael K. Wendt, PhD

Associate Professor, Purdue University, Lafayette, IN

 

Noah P. Zimmerman, PhD

Research Manager, Arm and Hammer, Waukesha, WI

 

Mahmoud Abu Eid, PhD
Consultant, McKinsey & Company

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