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Research Bench Lab
Microbiology & Immunology
Michael Dwinell, PhD

Michael B. Dwinell, PhD

Professor; Founding Director, Center for Immunology; Director, Bobbie Nick Voss Laboratory for Colon Cancer Research; Hanis-Stepka-Rettig Endowed Chair in Cancer Research

Locations

  • Microbiology & Immunology
    TBRC C3860

Contact Information

General Interests

Cancer Metastasis, Tumor Microenvironment, Mucosal Inflammation

Education

PhD, GI Pathophysiology, University of Wisconsin, Madison, 1996
Learn more about the Dwinell Lab

Biography

Dr. Dwinell, Hanis-Stepka-Rettig Endowed Chair in Cancer Research, is the Founding Director of the Center for Immunology following its inception in 2018. He has completed an MCW executive leadership training program at the Sheldon Lubar School of Business at the University of Wisconsin-Milwaukee as well as the Leadership for Social Inclusion & Equity Workshop developed by the National Coalition Building Institute. He has served on numerous NIH review panels and is currently chair of the Tumor Microenvironment study section.

Dr. Dwinell’s laboratory uses innovative strategies to reprogram the immune microenvironment to overcome immune suppression and evasion in pancreatic cancer. Specifically, his grant supported research examines chemokines as pivotal immune messengers regulating the tumor immune microenvironment. Dr. Dwinell oversees the immunology curriculum in Infectious Agents and Host Immunity and is past Director for Gastrointestinal & Nutritional Pathophysiology in the MCW medical school. He is course director of Mucosal Immunity and teaches in the Foundations in Biomedical Sciences and several other graduate school courses. He has frequently been named an Outstanding Medical Student and Outstanding Graduate Student Teacher and was recognized with the MCW Outstanding Mentor award in 2018.

Research Experience

  • Adjuvants, Immunologic
  • Carcinoma, Pancreatic Ductal
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Chemokines
  • Cytokines
  • Energy Metabolism
  • Immunity, Mucosal
  • Immuno-Oncology
  • Inflammation
  • Mice

Research Interests

My research interests currently focus on mechanisms tumor progression including remodeling the immune microenvironment. I use a variety of cellular, biochemical, and preclinical approaches to study the mechanisms immune-cancer cell communication essential for cancer progression.

Publications

  • (Roy I, Binder-Markey B, Willbanks A, Sychowski D, Phipps T, Barber A, McAllister D, D'Andrea D, Franz CK, Pichika R, Dwinell MB, Lieber RL.) J Appl Physiol (1985). 2024 Sep 01;137(3):705-717 PMID: 39052773 PMCID: PMC11424168 SCOPUS ID: 2-s2.0-85204163300 07/26/2024

  • (Drouillard D, Halyko M, Cinquegrani E, McAllister D, Peterson FC, Marchese A, Dwinell MB.) bioRxiv. 2024 Aug 27 PMID: 39253415 PMCID: PMC11383031 09/10/2024

  • (Roy I, Binder-Markey B, Sychowski D, Willbanks A, Phipps T, McAllister D, Bhakta A, Marquez E, D'Andrea D, Franz C, Pichika R, Dwinell MB, Jayabalan P, Lieber RL.) bioRxiv. 2023 Nov 15 PMID: 38014165 PMCID: PMC10680669 11/28/2023

  • (Keyes RF, McAllister D, Dwinell MB, Smith BC.) STAR Protoc. 2023 Sep 15;4(3):102437 PMID: 37552599 PMCID: PMC10424135 SCOPUS ID: 2-s2.0-85175638505 08/08/2023

  • (Mohan M, Janz S, Brazauskas R, Dwinell MB, Teng BQ, Yun G, Dong J, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, D'Souza A.) Bone Marrow Transplant. 2023 Aug;58(8):953-955 PMID: 37149674 PMCID: PMC10555486 SCOPUS ID: 2-s2.0-85158126520 05/07/2023

  • (Zhou AL, Jensen DR, Peterson FC, Thomas MA, Schlimgen RR, Dwinell MB, Smith BC, Volkman BF.) SLAS Discov. 2023 Jun;28(4):163-169 PMID: 36841432 PMCID: PMC10339762 SCOPUS ID: 2-s2.0-85149845436 02/26/2023

  • (Wu X, Clarke WR, Koplinski CA, Peterson FC, Dwinell MB, Wei G, Chao E, Huynh M, Yamada D, Volkman BF, Hwang ST.) J Immunol Methods. 2023 Apr;515:113453 PMID: 36863695 PMCID: PMC10715733 SCOPUS ID: 2-s2.0-85150034077 03/03/2023

  • (Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, Blumer JB, Luttrell LM, McCorvy JD, Hill WD.) ACS Pharmacol Transl Sci. 2023 Jan 13;6(1):22-39 PMID: 36659961 PMCID: PMC9844133 01/21/2023

  • (Vonderhaar EP, Dwinell MB, Craig BT.) Front Immunol. 2023;14:1202169 PMID: 37426669 PMCID: PMC10325564 SCOPUS ID: 2-s2.0-85164152167 07/10/2023

  • (Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, Blumer JB, Luttrell LM, McCorvy JD, Hill WD.) ACS Pharmacology and Translational Science. 13 January 2023;6(1):22-39 SCOPUS ID: 2-s2.0-85143982229 01/13/2023

  • (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB.) iScience. 2022 Dec 22;25(12):105670 PMID: 36567718 PMCID: PMC9768319 12/27/2022

  • (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB.) iScience. 22 December 2022;25(12) SCOPUS ID: 2-s2.0-85143723525 12/22/2022

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