皇家华人

CD8 T cells, T cell receptor, high throughput sequencing, cancer immunology, bioinformatics

Research Experience

皇家华人, 2022-present
Advisor: Weiguo Cui, PhD
Project: BCG-CAR empowers adoptive cell therapy to treat bladder cancer

UW-Madison, 2017 – 2020
Advisor: Zach Morris, MD/PhD and Ravi Patel, MD/PhD
Project: Examining the efficacy of bempegaldesleukin and anti-CTLA-4 at metastatic sites after combination with high dose radiation therapy in a preclinical non-small cell lung cancer model

Cambridge University, 2019
Advisor: Emma Rawlins, PhD
Project: Exploring human embryo stem cell alveolar differentiation

Publications

Chen Z, Ford KP, Islam MBAR, Wan H, Han H, Ramakrishnan A, Brown RJ, Villanueva V, Wang Y, Davis BT, Weiss C, Cui W, Gate D, Schwulst SJ. antiCD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury. bioRxiv [Preprint]. 2024 Jun 22:2024.06.17.596673. doi: 10.1101/2024.06.17.596673. PMID: 38948775; PMCID: PMC11212861.

Kasmani MY, Topchyan P, Brown AK, Brown RJ, Wu X, Chen Y, Khatun A, Alson D, Wu Y, Burns R, Lin CW, Kudek MR, Sun J, Cui W. A spatial sequencing atlas of age-induced changes in the lung during influenza infection. Nat Commun. 2023 Oct 18;14(1):6597. doi: 10.1038/s41467-023-42021-y. PMID: 37852965; PMCID: PMC10584893.

Kharel A, Shen J, Brown R, Chen Y, Nguyen C, Alson D, Bluemn T, Fan J, Gai K, Zhang B, Kudek M, Zhu N, Cui W. Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer. Cell Rep. 2023 Jun 27;42(6):112649. doi: 10.1016/j.celrep.2023.112649. Epub 2023 Jun 16. PMID: 37330910; PMCID: PMC10592487.

Thareja SK, Anfinson M, Cavanaugh M, Kim MS, Lamberton P, Radandt J, Brown R, Liang HL, Stamm K, Afzal MZ, Strande J, Frommelt MA, Lough JW, Fitts RH, Mitchell ME, Tomita-Mitchell A. Altered contractility, Ca2+ transients, and cell morphology seen in a patient-specific iPSC-CM model of Ebstein's anomaly with left ventricular noncompaction. Am J Physiol Heart Circ Physiol. 2023 Jul 1;325(1):H149-H162. doi: 10.1152/ajpheart.00658.2022. Epub 2023 May 19. PMID: 37204873; PMCID: PMC10312315.

Bates AM, Brown RJ, Pieper AA, Zangl LM, Arthur I, Carlson PM, Le T, Sosa GA, Clark PA, Sriramaneni RN, Kim K, Patel RB, Morris ZS. Combination of Bempegaldesleukin and Anti-CTLA-4 Prevents Metastatic Dissemination After Primary Resection or Radiotherapy in a Preclinical Model of Non-Small Cell Lung Cancer. Front Oncol. 2021 Apr 15;11:645352. doi: 10.3389/fonc.2021.645352. PMID: 33937052; PMCID: PMC8083981. 

Meeting Abstracts

Brown RJ, Amber Bates, Zangl L, et al. Combination of bempegaldesleukin and anti-CTLA-4 prevents metastatic dissemination after primary surgery or radiation therapy in a preclinical model of non-small cell lung cancer. Poster Presentation at: AACR, June 2020, San Diego CA.

Brown RJ, Hernandez R, Grudzinski JJ, Zangl L, Arthur I, Pieper A, Marsh IR, Bednarz B, Weichert J, Sondel PM, Morris ZS, and Patel R. Molecular radionucleotide therapy and anti-CTLA-4 prevent spontaneous metastases in a preclinical Lewis lung carcinoma model. Poster Presentation at: ASTRO, September 2019, Chicago IL.

General Interests

Movies, lifting weights, news