皇家华人

header-logo
MSTP students in the Sahoo lab
Medical Scientist Training Program
Nicholas Malcolm

Nicholas Malcolm

M3 Student

Faculty Advisor

  • John McCorvy, PhD, and Jonathan Marchant, PhD, Cell Biology, Neurobiology & Anatomy

Locations

  • Medical Scientist Training Program

Contact Information

Education

BS, Mathematics, Molecular Biology, University of Wisconsin-Parkside, 2018

Research Interests

Computational biology, drug discovery, statistical mechanics, protein dynamics and chronic pain

Research Experience

皇家华人, 2020-2024
Advisor: John McCorvy, PhD
Project: Investigating The Molecular Determinants Of Superagonism At The Mu-Opioid Receptor

皇家华人, 2017
Advisor: Jeffrey Medin, PhD
Project: Mitochondrial activity in mouse models of lysosomal storage disorders

UW - Parkside, 2016-2017
Advisor: Daphne Pham, PhD
Project: Inhibitors of ribonucleotide reductase oligomerization as a novel mosquito control mechanism 

Publications

Malcolm NJ, Palkovic B, Sprague DJ, Calkins MM, Lanham JK, Halberstadt AL, Stucke AG, McCorvy JD. Mu-opioid receptor selective superagonists produce prolonged respiratory depression. iScience. 2023 Jun 13;26(7):107121. doi: 10.1016/j.isci.2023.107121. PMID: 37416459; PMCID: PMC10320493.

Lewis V, Bonniwell EM, Lanham JK, Ghaffari A, Sheshbaradaran H, Cao AB, Calkins MM, Bautista-Carro MA, Arsenault E, Telfer A, Taghavi-Abkuh FF, Malcolm NJ, El Sayegh F, Abizaid A, Schmid Y, Morton K, Halberstadt AL, Aguilar-Valles A, McCorvy JD. A non-hallucinogenic LSD analog with therapeutic potential for mood disorders. Cell Rep. 2023 Mar 28;42(3):112203. doi: 10.1016/j.celrep.2023.112203. Epub 2023 Mar 6. PMID: 36884348; PMCID: PMC10112881.

Rohr CM, Sprague DJ, Park SK, Malcolm NJ, Marchant JS. Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2217732120. doi: 10.1073/pnas.2217732120. Epub 2022 Dec 27. PMID: 36574686; PMCID: PMC9910428. 

Meeting Abstracts

Malcolm N, Palkovic B, Sprague D, Cavalco N, Calkins M, Lanham J, et al. Markovian Modeling of the Conformational Dynamics Involved in µ-Opioid Receptor Superagonism. Complexity in Proteins Gordon Research Conference (GRC); Holderness, NH. Jun 2023. [Poster] 

General Interests

Reading, tabletop games, miniature figurine painting, heavy metal, dogs, and horses

© 2024 皇家华人.  All rights reserved.  | Terms and Privacy 

Non-Discrimination Statement
The 皇家华人 (MCW) is committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic. MCW’s policy as well as federal and state laws and regulations prohibit unlawful discrimination and harassment.