皇家华人

Adaptive NK cells, viral immuno-oncology, bioinformatics

Research Experience

皇家华人, 2020-2024
Advisors: Subramaniam Malarkannan, PhD and Scott Terhune, PhD
Project: Defining Memory NK cell development and functions following cytomegalovirus infection (TL1TR001437)

Illinois State University, 2015-2016
Advisor: Andres Vidal-Gadea, PhD
Project: Demonstrated that the nematode C. elegans is a viable system to study both the molecular and neuronal aspects of Angelman Syndrome

Illinois State University, 2014-2015
Advisor: Andres Vidal-Gadea, PhD
Project: Identify molecular machinery responsible for C. elegans ability to detect and orient to magnetic fields 

Publications

Khalil M, Terhune SS, Malarkannan S. Characterizing the single-cell transcriptomes of fetal NK cells isolated from the umbilical cord of fetuses exposed to human cytomegalovirus during gestation. Journal of Clinical and Translational Science, 2024;8(s1). doi: 10.1017/cts.2024.333. PMID: PMC11035326

Khalil M, Terhune SS, Malarkannan S. Human Cytomegalovirus Infection Promotes the Formation of NKG2CHi Memory NK Cells That Express Elevated Levels of IL-7R and Cyto-CD3ε. Blood 2023:142. https://doi.org/10.1182/blood-2023-174570.

Khalil M, Terhune SS, Malarkannan S. Single cell transcriptomes from HCMV+ donors reveal a unique NKG2CHi subset that represents true memory NK cells. Journal of Immunology 2023;244.01 doi: 10.104049/jimmmunol.210.Supp.244.01.

Khalil M, Terhune SS, Malarkannan S. 267 Defining the single-cell transcriptomes of splenic adaptive Natural Killer cells in donors with latent human cytomegalovirus infection. Journal of Clinical and Translational Science 2023;80. doi: 10.1017/cts.2023.326. PMID: PMC10129496

Khalil M, Malarkannan S. Innatus Immunis: Evolving paradigm of adaptive NK cells. Journal of Experimental Medicine 2022;1254. doi: 10.1084/jem.20221254. PMID: 36066493.

Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S. Method to Study Adaptive NK Cells Following MCMV Infections. Methods Mol Biol. 2022;2463:195-204. doi: 10.1007/978-1-0716-2160-8_14. PMID: 35344176.

Wang D, Burns R, Khalil M, Mei A, Hashemi E, Malarkannan S. Methods to Analyze the Developmental Trajectory of Human Primary NK Cells Using Monocle and SCENIC Analyses. Methods Mol Biol. 2022;2463:81-102. doi: 10.1007/978-1-0716-2160-8_7. PMID: 35344169.

Mei A, Hashemi E, Khalil M, Wang D, Malarkannan S. Isolation of Innate Lymphoid Cells from Murine Intestinal Lamina Propria. Methods Mol Biol. 2022;2463:3-9. doi: 10.1007/978-1-0716-2160-8_1. PMID: 35344163.

Hashemi E, Mei A, Wang D, Khalil M, Malarkannan S. Methods for Isolating and Defining Single-Cell Transcriptomes of Tissue-Resident Human NK Cells. Methods Mol Biol. 2022;2463:103-116. doi: 10.1007/978-1-0716-2160-8_8. PMID: 35344170.

Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S. Implications of a 'Third Signal' in NK Cells. Cells. 2021 Jul 31;10(8):1955. doi: 10.3390/cells10081955. PMID: 34440725; PMCID: PMC8393955."

Meeting Abstracts

Khalil M, Terhune SS, Human spleen serves as an environment for the persistence of long-lived Memory NKG2CHi NK cells capable of eliciting a robust recall response. 14th Annual Immunology Scientific Retreat, Center for Immunology. Milwaukee, WI. June 2024. [Poster]

Khalil M, Terhune SS, Malarkannan S. Single cell transcriptomes from fetuses exposed to HCMV during gestation reveals a distinct subset of memory-like NKG2C+ fetal NK cells. American Association of Immunologist 2024. Chicago, IL. May 2024. Top Abstract. [Poster]

Khalil M, Terhune SS, Malarkannan S. The single-cell transcriptomes of fetal NK cells unveil a distinctive subset crucial for the management of congenital cytomegalovirus infection. All Things Data Science Symposium. Milwaukee, WI. April 2024. [Poster]

Khalil M, Terhune SS, Malarkannan S. Characterizing the single-cell transcriptomes of fetal natural killer cells isolated from the umbilical cord of fetuses exposed to human cytomegalovirus during gestation. Association for Clinical and Translation Sciences. Las Vegas, NV. April 2024. Outstanding Abstract. [Poster]

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptomes of fetal NK cells reveal a unique NKG2CHi population that helps fetus manage congenital cytomegalovirus infection. MCW Research Week. Wauwatosa, WI. March 2024 . [Poster]

Khalil M, Terhune SS, Malarkannan S. Transcriptomic profiling of fetal NK cells derived from the umbilical cord of fetuses exposed to human cytomegalovirus during gestation. Department of Medicine. Wauwatosa, WI. March 2024 [Poster]

Ishaq A, Khalil M, Terhune SS, Malarkannan S. Single cell profiling reveals a unique Ly49HHi memory-like NK subset during MCMV infection. Cancer Center Trainee Symposium. Milwaukee, WI. March 2024. [Poster]

Khalil M, Terhune SS, Malarkannan S. Human cytomegalovirus infection promotes the formation of NKG2CHi memory NK cells that express elevated levels of IL-7R and cyto-CD3ï聛¥. American Society of Hematology. San Diego, CA. December 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptome of HCMV seropositive fetuses reveals a unique subset of NKG2C+ cells that represent adaptive NK cells. 33rd Annual Graduate School Poster Session. Milwaukee, WI. December 2023. [Poster]

Ishaq A, Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptomes of NK cells responding to MCMV infection reveal a distinct Ly49HHi memory subset emerging 7 days post-infection. Autumn Immunology Conference. Chicago, IL. November 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Memory NK cells are regulated by a unique transcriptional program allowing for their persistence in HCMV+ individuals. Autumn Immunology Conference. Chicago, IL. November 2023 [Poster]

Khalil M, Terhune SS, Malarkannan S. Fetal NK Cells: Identifying Their Role During Congenital Cytomegalovirus Infection. 12th Annual CTSI Milwaukee Regional Research Forum. Milwaukee, WI. October 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Cytomegalovirus infection induces the generation of NKG2CHi fetal NK cells in the umbilical cord. Midwest TL1 Summit. Wauwatosa, WI. September 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Human cytomegalovirus (HCMV) infection drives the formation of NKG2CHi memory NK cells that express elevated levels of IL-7R and cyto-CD3e. 38th Annual MD-PhD National Student Conference. Copper Mountain, CO. July 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Interleukin-7 Receptor (IL7R) and CD3E are necessary for the formation of NKG2CHi adaptive NK cells during HCMV infections. 13th Annual Immunology Scientific Retreat, Center for Immunology. Wauwatosa, WI. June 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Single cell transcriptomes from HCMV+ donors reveal a unique NKG2CHi subset that represents true memory NK cells. American Association of Immunologist 2023. Washington, D.C. May 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Defining the single-cell transcriptomes of splenic adaptive Natural Killer cells in donors with latent human cytomegalovirus infection. Association for Clinical and Translation Sciences. Washington, D.C. April 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Interleukin-7 Receptor (IL7R) and CD3E are necessary for the development and function of NKG2CHi memory-like NK cells during HCMV infections. 6th Annual Graduate School Symposium. Milwaukee, WI. April 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptomes reveal a unique NKG2CHi population representing memory NK cells. MCW Research Week. Wauwatosa, WI. March 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptome from the spleen of HCMV+ donors reveal a unique subset of NKG2C+ population that represent true memory NK cells. Department of Medicine. Wauwatosa, WI. March 2023. [Poster]

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptome of human adaptive NK cells reveal a unique transcriptional program that governs its development and function. Autumn Immunology Conference. Chicago, IL. November 2022. [Poster]

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptome of HCMV seropositive individuals reveals a unique subset of NKG2C+ cells that represent adaptive NK cells. 32nd Annual Graduate School Poster Session. Wauwatosa, WI. October 2022. [Poster]

Khalil M, Terhune SS, Malarkannan S. Transcriptome of human adaptive NK cells reveal a unique transcriptional program that governs its development and function. 11th Annual CTSI Milwaukee Regional Research Forum. Milwaukee, WI. October 2022. [Poster]

Khalil M, Terhune SS, Malarkannan S. Transcriptomic profiling of human Adaptive NK cells derived from HCMV seropositive individuals. 1st Annual Midwest TL1 Research Summit. Madison, WI. September 2022. [Poster]

Khalil M, Terhune SS, Malarkannan S. Defining the Human Cytomegalovirus manipulation of NK cells at a single-cell resolution. 12th Annual Immunology Scientific Retreat, Center for Immunology. Wauwatosa, WI. June 2022. [Poster]

Khalil M, Patel J.J, Baruah D, Rein L.R, Tsai S, Clarke C, T. Gamblin C, Mogal H. Association of Muscle Quantity and Frailty on Short-term Outcomes of CRS/HIPEC in Patients with Appendiceal cancer. SSO 2020 International Advanced Cancer Therapies. Orlando, Florida. February 2020. [Poster]

General Interests

Traveling, running, snowboarding, scuba diving, reading and MMA