皇家华人

Transcriptional biology, cancer biology, chemical biology, drug discovery

Research Experience

The Scripps Research Institute, April 2023-May 2024
Advisor: Michael Erb, PhD
Project: Developing high-throughput direct to biology chemistries for molecular glue degrader discovery

University of California San Diego, November 2021-April 2023
Advisor: Peter Zage, MD, PhD
Project: Characterizing novel inhibitors of FEN1 and RET in neuroblastoma models

University of California San Francisco, April 2021-April 2024
Advisor: Lauren Meyer, MD, PhD
Project: Analysis of deidentified HLH patient data and development of computational methods to predict pathogenicity of variants of unknown significance in familial HLH genes

Publications

Steen EA, Basilaia M, Kim W, Getz T, Gustafson JL, Zage PE. Targeting the RET tyrosine kinase in neuroblastoma: A review and application of a novel selective drug design strategy. Biochem Pharmacol. 2023 Oct;216:115751. doi: 10.1016/j.bcp.2023.115751. Epub 2023 Aug 16. PMID: 37595672; PMCID: PMC10911250.

Steen EA, Patterson ME, Rivera-Vega M, Phillips SA. Abnormal thyroid function: an unusual presentation of pituitary stalk interruption syndrome. Endocrinol Diabetes Metab Case Rep. 2023 May 15;2023(2):23-0021. doi: 10.1530/EDM-23-0021. PMID: 37183887; PMCID: PMC10337263.

Steen EA, Nichols KE, Meyer LK. Insights into the cellular pathophysiology of familial hemophagocytic lymphohistiocytosis. Front Immunol. 2023 Mar 9;14:1147603. doi: 10.3389/fimmu.2023.1147603. PMID: 36969228; PMCID: PMC10033680.

Steen EA, Hermiston ML, Nichols KE, Meyer LK. Digenic Inheritance: Evidence and Gaps in Hemophagocytic Lymphohistiocytosis. Front Immunol. 2021 Nov 17;12:777851. doi: 10.3389/fimmu.2021.777851. PMID: 34868048; PMCID: PMC8635482.

Meeting Abstracts

Meyer L, Steen E, Olshen A, Zinter M, Nichols K, Keenan C. The HLH predictive index: a rapid and accessible diagnostic screening tool for identification of pediatric patients with probable HLH. Histiocyte Society Annual Meeting, 2024.

Steen E, Meyer L, Miller D, Malinverni D, Olshen A, Nichols K. (2023, October 23). Using protein modeling to evaluate the functional consequences of patient-derived missense variants in perforin. [Poster presentation]. Histiocyte Society Annual Meeting, 2023, Athens, Greece.

Steen EA, Basilaia M, Gustafson J, Zage PE. (2023, May 18). Atropisomeric pyrrolopyrimidine inhibitor selectively targets the RET tyrosine kinase in neuroblastoma. [Poster presentation]. UCSD ACS-SA 2023 Symposium, University of California, San Diego, CA, United States.

Meyer L, Steen E, Hermiston M, Olshen A, Nichols K, Zinter M. A Real-World Analysis of the Diagnostic Evaluation for Hemophagocytic Lymphohistiocytosis in a Pediatric Population. American Society of Hematology (ASH) Annual Meeting, 2023.

Steen E, Meyer L, Miller D, Olshen A, Nichols K. Using protein modeling to evaluate the functional consequences of patient-derived missense variants in familial HLH. Histiocyte Society Annual Meeting, 2023.

Meyer L, Huang I, Huang B, Steen E, Chung J, Pawar A, Hermiston M, Ohgami R, Ruiz-Cordero R, Bhargava P, Marinoff A. Clonally related T-cell malignancies and hemophagocytic lymphohistiocytosis in a pediatric patient. Histiocyte Society Annual Meeting, 2022.

General Interests

Specialty coffee, music, hiking, and cooking

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