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Physiology
Anne E. Kwitek, PhD

Anne E. Kwitek, PhD

Professor, Physiology & Medicine

Locations

  • Physiology

Contact Information

Education

BS, Biology and Chemistry, University of Wisconsin at Stevens Point
PhD, Interdisciplinary Graduate Program in Genetics, University of Iowa

Biography

Dr. Anne Kwitek is a tenured Professor in the Department of Physiology. She earned her PhD in Genetics at the University of Iowa then came to MCW as a postdoctoral fellow. After growing the ranks to Associate Professor at MCW, Dr. Kwitek was recruited back to the University of Iowa where she remained until her return to MCW in 2019.

Dr. Kwitek is an animal and human geneticist whose research revolves around the genetics of complex disease with an emphasis on hypertension, obesity, diabetes, and the metabolic syndrome (MetS). She currently has two major laboratory research interests. The first involves understanding the genetic susceptibility to complex human diseases, with a focus on obesity, hypertension, diabetes, and cardiometabolic disease. The approach involves integrating genetics, genomics, and other ‘omics’ approaches to identify genes and mechanisms leading to complex disease using rat models and human populations. She is also studying how genomic variation affects and is affected by environmental stimuli to influence susceptibility to cardiometabolic disease.

Dr. Kwitek also leads the Rat Genome Database (RGD) and is a member of the Alliance of Genome Resources (Alliance). The goal of RGD (and the Alliance) is to provide a research platform that delivers the data and tools necessary for investigators to advance preclinical and translational research. This involves acquiring, validating, and integrating comprehensive genetic, genomic, phenotype and disease datasets for rat as well as human, mouse and other mammals used as human disease models. RGD has numerous disease portals dedicated to providing a centralized disease-based data and analysis environment for diseases such as obesity and metabolic syndrome, diabetes, renal disease, and cardiovascular disease to name a few.

Research Areas of Interest

  • Cardiovascular Diseases
  • Computational Biology
  • Database Management Systems
  • Databases, Genetic
  • Disease Models, Animal
  • Gene Expression Regulation
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome, Human
  • Genomics
  • Hypertension

MCW Program / Core Facilities

  • Biomedical Engineering (PhD)
  • CTSI Obesity Ensemble
  • Interdisciplinary Doctoral Program in Biomedical Sciences
  • Physiology (PhD)

Research Interests

Dr. Kwitek’s major research focus involves understanding the genetic susceptibility to complex human diseases, with a focus on obesity, hypertension, and cardiometabolic disease. The approach involves integrating genetics, genomics, and other ‘omics’ approaches to identify genes and mechanisms leading to complex disease using rat models and human populations. Her studies also involve how genomic variation affects and is affected by environmental stimuli to influence susceptibility to cardiometabolic disease.

Publications

  • (Thareja SK, Yang X, Upama PB, Abdullah A, Torres SP, Cocroft LJ, Bubolz M, McGaughey K, Lou X, Kamaraju S, Ahamed SI, Madiraju P, Kwitek AE, Whittle J, Franco Z.) J Am Med Inform Assoc. 2024 Dec 01;31(12):2940-2951 PMID: 39441983 PMCID: PMC11631115 10/23/2024

  • (Li K, Smith ML, Blazier JC, Kochan KJ, Wood JMD, Howe K, Kwitek AE, Dwinell MR, Chen H, Ciosek JL, Masterson P, Murphy TD, Kalbfleisch TS, Doris PA.) Genome Res. 2024 Nov 20;34(11):2081-2093 PMID: 39516046 PMCID: PMC11610589 SCOPUS ID: 2-s2.0-85209718679 11/13/2024

  • (Wildes MP, Fernando DG, Grobe CC, Reho JJ, Grobe JL, Kidambi S, Kindel TL, Kwitek AE, Segar JL, Williams JS, Morselli LL.) Endocrinology. 2024 Aug 27;165(10) PMID: 39236000 PMCID: PMC11408931 SCOPUS ID: 2-s2.0-85204510410 09/05/2024

  • (Kemmo Tsafack U, Ahn KW, Kwitek AE, Lin CW.) Bioengineering (Basel). 2024 Jun 08;11(6) PMID: 38927823 PMCID: PMC11201102 06/27/2024

  • (Alliance of Genome Resources Consortium .) Genetics. 2024 May 07;227(1) PMID: 38552170 PMCID: PMC11075569 SCOPUS ID: 2-s2.0-85193063498 03/29/2024

  • (de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chen D, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts AM, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Solberg Woods LC, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MR, Williams RW, Li JZ, Chen H.) Cell Genom. 2024 Apr 10;4(4):100527 PMID: 38537634 PMCID: PMC11019364 03/28/2024

  • (Morselli LL, Amjad R, James R, Kindel TL, Kwitek AE, Williams JS, Grobe JL, Kidambi S.) J Endocr Soc. 2024 Apr 06;8(6):bvae062 PMID: 38623381 PMCID: PMC11017326 SCOPUS ID: 2-s2.0-85190716270 04/16/2024

  • (Armoundas AA, Narayan SM, Arnett DK, Spector-Bagdady K, Bennett DA, Celi LA, Friedman PA, Gollob MH, Hall JL, Kwitek AE, Lett E, Menon BK, Sheehan KA, Al-Zaiti SS, American Heart Association Institute for Precision Cardiovascular Medicine; Council on Cardiovascular and Stroke Nursing; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; and Stroke Council.) Circulation. 2024 Apr 02;149(14):e1028-e1050 PMID: 38415358 PMCID: PMC11042786 SCOPUS ID: 2-s2.0-85189451613 02/28/2024

  • (Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL.) Physiol Genomics. 2024 Mar 01;56(3):265-275 PMID: 38145289 PMCID: PMC10866620 SCOPUS ID: 2-s2.0-85185200180 12/25/2023

  • (Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Brozoski DT, Wackman KK, Lu KT, Kozak KN, Wells C, Fogo AB, Gibson-Corley KN, Kwitek AE, Sigmund CD, McIntosh JJ, Grobe JL.) Sci Adv. 2023 Dec;9(48):eadg8118 PMID: 38039359 PMCID: PMC10691776 SCOPUS ID: 2-s2.0-85178323055 12/01/2023

  • (Alliance of Genome Resources Consortium .) bioRxiv. 2023 Nov 22 PMID: 38045425 PMCID: PMC10690154 12/04/2023

  • (Wagner VA, Holl KL, Clark KC, Reho JJ, Lehmler HJ, Wang K, Grobe JL, Dwinell MR, Raff H, Kwitek AE.) Endocrinology. 2023 Nov 02;164(12) PMID: 37882530 PMCID: PMC10637104 SCOPUS ID: 2-s2.0-85176509096 10/26/2023

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