Suresh Kumar, PhD

Associate Professor; Scientific Director, CRI Imaging Core; Scientific Director, NRC Imaging Facility

Locations

Pathology & Laboratory Medicine

Contact Information

Education

PhD, Biochemistry, Osmania University, India, 1998

Biography

Endothelial dysfunction could be due to aberrant growth pattern or localized signal perturbations that results in growth malformation, compromised vascular function, increased cardiovascular disease risk, etc. My research is focused on understanding the endothelial cell function / dysfunction in vascular anomalies such as infantile hemangioma, Sturge-Weber syndrome and Cobb syndrome. My lab had been studying the endothelial cell function under moderate and excess levels of oxidative stress and its effects on vascular integrity and physiology. We specifically follow two catabolizing enzymes viz., nitric oxide synthase and indoleamine 2,3-dioxygenase to understand bioavailability of vasodilators and other catabolites that contribute to endothelial function, growth and cell death. Using proteomic, imaging and biochemical tools we are attempting to elucidate patterns of endothelial cell function / dysfunction.

My lab also studies congenital heart disease associated endothelial dysfunction. Genetic mutations that affect vital regulatory and functional gene products cause disease conditions and the manifestation of the disease is depicted in many ways including endothelial dysfunction. My lab studies the fatty acid deficiency related heart disease and are focused on understanding the relationship between the heart condition and endothelial cell function in disease progression.

I also serve as the Scientific Director of Children’s Wisconsin Research Institute's Imaging Core and 皇家华人 – Neuroscience Research Institutes Imaging Core and I teach microscopy and analytical methods along with hands on training on several light microscopic instruments and scanners. In this collaborative environment, I advise on experimental design, sample preparation, data acquisition, processing and analyzing data. The core houses bright field, fluorescence, confocal, 2 photon confocal, laser micro dissection, laser scanning cytometry, fluorescence slide scanning and bright field slide scanner. The facility enables acquisition of high quality 2D, 3D, 4D and 5D images and quantification by several methods for reproducible, automatic and high levels of accuracy. My lab collaborates with several of the investigators and participate in their studies to further their knowledge and understanding.

MCW Program / Core Facilities

CRI Imaging Core

Research Interests

Endothelial dysfunction and vascular malformation

Oxidative stress and cardiovascular diseases

Imaging tools for cancer research

(Lawlor MW, Schoser B, Margeta M, Sewry CA, Jones KA, Shieh PB, Kuntz NL, Smith BK, Dowling JJ, Müller-Felber W, Bönnemann CG, Seferian AM, Blaschek A, Neuhaus S, Foley AR, Saade DN, Tsuchiya E, Qasim UR, Beatka M, Prom MJ, Ott E, Danielson S, Krakau P, Kumar SN, Meng H, Vanden Avond M, Wells C, Gordish-Dressman H, Beggs AH, Christensen S, Conner E, James ES, Lee J, Sadhu C, Miller W, Sepulveda B, Varfaj F, Prasad S, Rico S.) EBioMedicine. 2024 Jan;99:104894 PMID: 38086156 PMCID: PMC10758703 SCOPUS ID: 2-s2.0-85179618072 12/13/2023
(Eisa-Beygi S, Hu MM, Kumar SN, Jeffery BE, Collery RF, Vo NJ, Lamichanne BS, Yost HJ, Veldman MB, Link BA.) Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):e231-e237 PMID: 37128914 PMCID: PMC10330147 SCOPUS ID: 2-s2.0-85163499929 05/02/2023
(Sidlowski P, Czerwinski A, Liu Y, Liu P, Teng RJ, Kumar S, Wells C, Pritchard K Jr, Konduri GG, Afolayan AJ.) Am J Respir Cell Mol Biol. 2023 Apr;68(4):395-405 PMID: 36481055 PMCID: PMC10112427 SCOPUS ID: 2-s2.0-85151575149 12/09/2022
(Kim J, Yang Y, Hong SK, Zielonka J, Dash RK, Audi SH, Kumar SN, Joshi A, Zimmerman MA, Hong JC.) Am J Physiol Gastrointest Liver Physiol. 2022 Aug 01;323(2):G126-G133 PMID: 35700191 SCOPUS ID: 2-s2.0-85134761396 06/15/2022
(Puzyrenko A, Kumar SN, Pantazis CG, Iczkowski KA.) Ann Diagn Pathol. 2022 Aug;59:151956 PMID: 35509134 SCOPUS ID: 2-s2.0-85129373666 05/06/2022
(Hamm SE, Fathalikhani DD, Bukovec KE, Addington AK, Zhang H, Perry JB, McMillan RP, Lawlor MW, Prom MJ, Vanden Avond MA, Kumar SN, Coleman KE, Dupont JB, Mack DL, Brown DA, Morris CA, Gonzalez JP, Grange RW.) Mol Ther Methods Clin Dev. 2021 Dec 10;23:460 PMID: 34820472 PMCID: PMC8585580 11/26/2021
(Hamm SE, Fathalikhani DD, Bukovec KE, Addington AK, Zhang H, Perry JB, McMillan RP, Lawlor MW, Prom MJ, Vanden Avond MA, Kumar SN, Coleman KE, Dupont JB, Mack DL, Brown DA, Morris CA, Gonzalez JP, Grange RW.) Mol Ther Methods Clin Dev. 2021 Jun 11;21:144-160 PMID: 33850950 PMCID: PMC8020351 04/15/2021
(Hu W, Liu Z, Salato V, North PE, Bischoff J, Kumar SN, Fang Z, Rajan S, Hussain MM, Miao QR.) JCI Insight. 2021 Feb 08;6(3) PMID: 33400686 PMCID: PMC7934876 SCOPUS ID: 2-s2.0-85102090712 01/06/2021
(Arzua T, Yan Y, Jiang C, Logan S, Allison RL, Wells C, Kumar SN, Schäfer R, Bai X.) Transl Psychiatry. 2021 Feb 01;11(1):87 PMID: 33526769 PMCID: PMC7851120 SCOPUS ID: 2-s2.0-85100273287 02/03/2021
(Foomani FH, Jarzembowski JA, Mostaghimi S, Mehrvar S, Kumar SN, Ranji M.) IEEE J Transl Eng Health Med. 2021;9:1800407 PMID: 34462673 PMCID: PMC8396955 SCOPUS ID: 2-s2.0-85113252876 09/01/2021
(Arzua T, Yan Y, Jiang C, Logan S, Allison RL, Wells C, Kumar SN, Schäfer R, Bai X.) Transl Psychiatry. 2020 Oct 13;10(1):347 PMID: 33051447 PMCID: PMC7553959 SCOPUS ID: 2-s2.0-85092448660 10/15/2020
(Kim J, Hagen CE, Kumar SN, Park JI, Zimmerman MA, Hong JC.) Transplant Direct. 2020 Aug;6(8):e584 PMID: 32766432 PMCID: PMC7371100 SCOPUS ID: 2-s2.0-85094858644 08/09/2020

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