Ross Collery, PhD

Associate Professor of Ophthalmology & Visual Sciences; Associate Professor of Cell Biology, Neurobiology and Anatomy

Locations

皇家华人 Eye Institute
925 N. 87 St. Room 827
Milwaukee, WI 53226

Contact Information

Education

PhD, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
MSc, Molecular Genetics, Trinity College, Dublin, Ireland
BA (Mod), Genetics, Trinity College, Dublin, Ireland

Biography

Dr. Collery received his Bachelor of Science (specializing in Genetics) from Trinity College Dublin in 2000 and received his master’s degree in genetics from the same institution in 2003.

Dr. Collery then went on to obtain his PhD in Genetics from University College Dublin in 2008, where his research with Dr. Breandán Kennedy focused on using zebrafish to study both phototransduction in the eye, as well as the visual cycle. During his graduate career, he helped to characterize components of the cone and rod visual cycles, as well as applying emerging transgenic methods to express human proteins in zebrafish photoreceptors.

During his postdoctoral career, he worked with Dr. Brian Link at MCW studying the effects of BMP signaling and LRP2 function on eye size and refractive error.

Today, Dr. Collery continues to study pathways in the eye that contribute to vision, refractive error and retinoid trafficking.

Dr. Collery became a faculty member at the 皇家华人 Eye Institute in 2016.

Research Interests

The Collery lab studies studies refractive error and retinal degeneration in the eye, and how they influence one another, often having a common genetic cause.

Refractive error is common in inherited retinal degenerations, and conversely, refractive error can lead to retinal damage and degeneration.

We are especially interested in retinoids, compounds derived from vitamin A, that control many functions of the eye. Mutations in retinoid transport proteins have been shown to cause refractive error and photoreceptor loss. For example, mutations in human STRA6, a retinoid receptor found on the retinal pigment epithelial layer, cause Matthew-Wood syndrome, characterized by microphthalmia and coloboma.

To better understand how retinoids influence the development and health of the eye, we use a host of cutting-edge techniques, including:

CRISPR/Cas9 genomic editing (Figure 1)
Live imaging of the eye and retina using optical coherence tomography (OCT) (Figure 2)
Refractive error measurement (Figure 3)
Transgenic animal models (Figure 4; Movie 1)
Fluorescent protein imaging (Figure 4)
RNAseq transcriptomic profiling

(McCann T, Sundaramurthi H, Walsh C, Virdi S, Alvarez Y, Sapetto-Rebow B, Collery RF, Carter SP, Moran A, Mulholland R, O'Connor JJ, Taylor MR, Rauch N, Starostik MR, English MA, Swaroop A, Geisler R, Reynolds AL, Kennedy BN.) FASEB J. 2024 Oct 15;38(19):e70086 PMID: 39360639 SCOPUS ID: 2-s2.0-85205528183 10/03/2024
(Nonarath HJT, Simpson SL, Slobodianuk TL, Collery RF, Dinculescu A, Link BA.) bioRxiv. 2024 Mar 01 PMID: 38464015 PMCID: PMC10925332 03/11/2024
(Eisa-Beygi S, Hu MM, Kumar SN, Jeffery BE, Collery RF, Vo NJ, Lamichanne BS, Yost HJ, Veldman MB, Link BA.) Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):e231-e237 PMID: 37128914 PMCID: PMC10330147 SCOPUS ID: 2-s2.0-85163499929 05/02/2023
(Young JB, Al-Kirwi KY, Wynne N, Buchberger AR, Skumatz CMB, Collery RF, Kassem IS.) Exp Eye Res. 2022 Dec;225:109219 PMID: 35985530 PMCID: PMC9910826 SCOPUS ID: 2-s2.0-85140298482 08/20/2022
(Moran AL, Fehilly JD, Floss Jones D, Collery R, Kennedy BN.) FASEB J. 2022 Oct;36(10):e22556 PMID: 36165194 PMCID: PMC9828801 SCOPUS ID: 2-s2.0-85138598327 09/28/2022
(Brandt ZJ, Collery RF, Besharse JC, Link BA.) Invest Ophthalmol Vis Sci. 2021 Dec 01;62(15):13 PMID: 34913948 PMCID: PMC8684298 SCOPUS ID: 2-s2.0-85122380090 12/17/2021
(Salmon AE, Chen RC, Atry F, Gaffney M, Merriman DK, Gil DA, Skala MC, Collery R, Allen KP, Buckland E, Pashaie R, Carroll J.) Transl Vis Sci Technol. 2021 Jul 01;10(8):5 PMID: 34232271 PMCID: PMC8267221 SCOPUS ID: 2-s2.0-85111034709 07/08/2021
(Ferre-Fernández JJ, Sorokina EA, Thompson S, Collery RF, Nordquist E, Lincoln J, Semina EV.) Hum Mol Genet. 2020 Sep 29;29(16):2723-2735 PMID: 32720677 PMCID: PMC7530528 SCOPUS ID: 2-s2.0-85092681312 07/29/2020
(Huckenpahler AL, Lookfong NA, Warr E, Heffernan E, Carroll J, Collery RF.) Transl Vis Sci Technol. 2020 Sep;9(10):18 PMID: 32983626 PMCID: PMC7500127 SCOPUS ID: 2-s2.0-85091664660 09/29/2020
(Clark BS, Miesfeld JB, Flinn MA, Collery RF, Link BA.) Front Cell Dev Biol. 2020;8:608112 PMID: 33634099 PMCID: PMC7900515 SCOPUS ID: 2-s2.0-85101223534 02/27/2021
(Collery RF, Link BA.) Front Cell Dev Biol. 2019;7:167 PMID: 31457013 PMCID: PMC6700241 SCOPUS ID: 2-s2.0-85072723134 08/29/2019
(Hanovice NJ, Leach LL, Slater K, Gabriel AE, Romanovicz D, Shao E, Collery R, Burton EA, Lathrop KL, Link BA, Gross JM.) PLoS Genet. 2019 Jan;15(1):e1007939 PMID: 30695061 PMCID: PMC6368336 SCOPUS ID: 2-s2.0-85061272556 01/30/2019