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Hematology and Oncology
Siegfried Janz, MD

Siegfried Janz, MD

Professor and William G. Schuett, Jr., Multiple Myeloma Endowed Chair; Director of Myeloma Biology Program

Locations

  • MFRC 6037
    Hematology and Oncology - Medicine
    Bone Marrow Transplant Program
    Cancer Center - Froedtert Hospital
Learn more about the Janz Lab

Biography

Siegfried Janz, MD, DSc, Professor and William G. Schuett, Jr., Multiple Myeloma Endowed Chair directs translational wet bench myeloma research at the Division of Hematology and Oncology, Department of Medicine, 皇家华人 Milwaukee. He obtained his medical degree and board certification in Clinical Immunology from the University of Leipzig, Germany, and then joined the National Cancer Institute, NIH, to receive advanced training in biology and genetics of plasma cell tumor development. In 2007 he was appointed Research Professor at the Department of Pathology, Carver College of Medicine, University of Iowa. In 2018 he relocated his laboratory to Milwaukee, where he works in close association with clinical colleagues to enhance our understanding of the natural history of myeloma and improve the outcome of multiple myeloma.

Research Interests

The William G. Schuett, Jr., Multiple Myeloma Research Laboratory relies on continuous human myeloma cell lines and genetically engineered mouse models of human myeloma to elucidate mechanisms of malignant plasma cell development and evaluate new approaches to myeloma treatment and prevention. Working in close association with our clinical colleagues in the Division of Hematology and Oncology, we employ a bench-to-bedside-and-back strategy to translate advances in the laboratory to improving outcomes of multiple myeloma. We recently completed an NCI-supported project on genetic pathways of plasma cell neoplasia (2R01CA151354) and now concentrate on the design and testing of a novel immunotherapy for myeloma that takes advantage of autologous CAR T cells to seek out and kill aberrant plasma cells in bone marrow and extramedullary tissue sites. This ongoing project is generously supported by a grant from the Riney Family Multiple Myeloma Research Initiative.

Publications

  • (Yu M, Zhou V, Pisano MD, Janz S, Cui X.) Exp Cell Res. 2024 Oct 01;442(2):114273 PMID: 39370095 SCOPUS ID: 2-s2.0-85206163386 10/07/2024

  • (Zhou V, Yu M, Fu J, Janz S, Cui X.) J Transl Med. 2024 Jul 08;22(1):638 PMID: 38977990 PMCID: PMC11232139 SCOPUS ID: 2-s2.0-85197753777 07/09/2024

  • (Li JR, Arsang-Jang S, Cheng Y, Sun F, D'Souza A, Dhakal B, Hari P, Huang Q, Auer P, Li Y, Urrutia R, Zhan F, Shaughnessy JD Jr, Janz S, Dong J, Cheng C.) Blood Cancer J. 2024 Mar 06;14(1):38 PMID: 38443358 PMCID: PMC10915134 SCOPUS ID: 2-s2.0-85186929795 03/06/2024

  • (Hammons L, Haider S, Portuguese AJ, Banerjee R, Szabo A, Pasquini M, Chhabra S, Radhakrishnan S, Mohan M, Narra R, Dong J, Janz S, Shah NN, Hamadani M, D'Souza A, Hari P, Dhakal B.) Br J Haematol. 2024 Mar;204(3):887-891 PMID: 38054558 SCOPUS ID: 2-s2.0-85178904872 12/06/2023

  • (Hammons L, Szabo A, Janardan A, Bhatlapenumarthi V, Annyapu E, Dhakal B, Al Hadidi S, Radhakrishnan SV, Narra R, Bhutani D, Thanendrarajan S, Janz S, Zangari M, Lentzsch S, Van Rhee F, Crescencio JCR, D'Souza A, Chakraborty R, Mohan M, Schinke C.) Haematologica. 2024 Mar 01;109(3):906-914 PMID: 37646658 PMCID: PMC10905074 SCOPUS ID: 2-s2.0-85178101970 08/30/2023

  • (Buradagunta CS, Arsang-Jang S, Massat B, Thapa B, Patek V, D'Souza A, Auer P, Urrutia R, Janz S, Dhakal B, Hari P, Dong J.) Leukemia. 2024 Feb;38(2):383-385 PMID: 37919604 PMCID: PMC11326531 SCOPUS ID: 2-s2.0-85175540732 11/03/2023

  • (Sun F, Cheng Y, Wanchai V, Guo W, Mery D, Xu H, Gai D, Siegel E, Bailey C, Ashby C, Al Hadidi S, Schinke C, Thanendrarajan S, Ma Y, Yi Q, Orlowski RZ, Zangari M, van Rhee F, Janz S, Bishop G, Tricot G, Shaughnessy JD Jr, Zhan F.) Nat Commun. 2024 Jan 19;15(1):615 PMID: 38242888 PMCID: PMC10798961 SCOPUS ID: 2-s2.0-85182665152 01/20/2024

  • (Mohan M, Kothari A, Verhagen N, Shreenivas A, Radhakrishnan SV, Dhakal B, Figueroa-Castro C, Chhabra S, Janz S, Pasquini M, Hamadani M, Szabo A, D'Souza A, N3C consortium.) Bone Marrow Transplant. 2024 Jan;59(1):121-124 PMID: 37803198 SCOPUS ID: 2-s2.0-85173730029 10/07/2023

  • (Pisano MD, Sun F, Cheng Y, Parashar D, Zhou V, Jing X, Sompallae R, Abrudan J, Zimmermann MT, Mathison A, Janz S, Pufall MA.) Haematologica. 2023 Dec 01;108(12):3372-3383 PMID: 37439384 PMCID: PMC10690922 SCOPUS ID: 2-s2.0-85178652041 07/13/2023

  • (Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Guo W, Cao H, Zhu Y, Ashby C, Bauer MA, Nookaew I, Siegel ER, Ying J, Chen JR, Gai D, Peng B, Xu H, Bailey C, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, Chesi M, Bergsagel PL, van Rhee F, Janz S, Tricot G, Shaughnessy JD Jr, Zhan F.) Cell Rep Med. 2023 Oct 17;4(10):101214 PMID: 37794587 PMCID: PMC10591052 SCOPUS ID: 2-s2.0-85173718596 10/05/2023

  • (Mohan M, Janz S, Brazauskas R, Dwinell MB, Teng BQ, Yun G, Dong J, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, D'Souza A.) Bone Marrow Transplant. 2023 Aug;58(8):953-955 PMID: 37149674 PMCID: PMC10555486 SCOPUS ID: 2-s2.0-85158126520 05/07/2023

  • (Sun F, Cheng Y, Ying J, Mery D, Al Hadidi S, Wanchai V, Siegel ER, Xu H, Gai D, Ashby TC, Bailey C, Chen JR, Schinke C, Thanendrarajan S, Zangari M, Janz S, Barlogie B, Van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F.) J Hematol Oncol. 2023 Jun 29;16(1):70 PMID: 37386588 PMCID: PMC10308756 SCOPUS ID: 2-s2.0-85163879552 06/30/2023

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