Michael T. Zimmermann, PhD
Director, Computational Structural Genomics Unit, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine
Locations
- Mellowes Center
Research Areas of Interest
- Chromatin
- Chromosomal Proteins, Non-Histone
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genetic Variation
- Genomics
- Human Genetics
- Molecular Dynamics Simulation
- Multiprotein Complexes
- Mutation
- Mutation, Missense
- Neoplasms
Leadership Positions
- Assistant Professor of Bioinformatics - Clinical and Translational Science Institute, 皇家华人
- Director, Computational Structural Genomics Unit, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine
- MCW Program and Course Director, Joint Program in Bioinformatics between Marquette University and 皇家华人
- MCW Research Computing Center, Faculty Advisory Committee; Chair (elected, 2022-2024), Co-Chair (elected, 2020-2022), and Member (2020-Present)
- Strategic Steering Committee, Data Science Institute, 皇家华人
- Visiting Assistant Professor 鈥� Department of Mathematics, Marquette University
Research Interests
- Rare and undiagnosed genetic diseases of children and adults
- Mechanistic understanding of chromatinopathies, defined as human diseases driven by alteration of epigenetic enzymes and the dysregulation of chromatin organization and
regulation, with a specific focus on the human BAF complex – a SWI/SNF family chromatin remodeling enzyme - Molecular modeling and protein complex prediction for interpreting mechanisms of human diseases (spanning heritable, non-heritable, and cancer)
- Translating our approaches from rare disease and rare cancers to our Community-Oriented and Genomics-Informed research program. In this new program, “Everyone is
oof-One.” That is, as datasets grow, we are identifying that everyone has unique and distinct genetic differences. New approaches are needed to better understand the health
relevance of N-of-one variation. - Our lab stands at the forefront of biomedical innovation, fusing cutting-edge genomics with advanced computational modeling to unlock the secrets of human health and disease. We've pioneered novel approaches to understanding cancer biology, immune system function, and rare genetic disorders, leading to breakthroughs in personalized medicine research. Our team has identified crucial genetic variants driving rare diseases, providing hope to families worldwide, developed powerful computational tools for analyzing complex biological data, and uncovered new mechanisms in cancer development. Through our multidisciplinary approach, we're not just advancing scientific knowledge - we're paving the way for more precise diagnostics and targeted therapies that promise to transform patient care across a spectrum of conditions.
Publications
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(Pollin G, Chi YI, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R.) Epigenomics. 2025 Jan;17(1):5-20 PMID: 39632680 PMCID: PMC11703355 SCOPUS ID: 2-s2.0-85210974733 12/05/2024
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(Gong M, Li J, Qin Z, Machado Bressan Wilke MV, Liu Y, Li Q, Liu H, Liang C, Morales-Rosado JA, Cohen ASA, Hughes SS, Sullivan BR, Waddell V, van den Boogaard MH, van Jaarsveld RH, van Binsbergen E, van Gassen KL, Wang T, Hiatt SM, Amaral MD, Kelley WV, Zhao J, Feng W, Ren C, Yu Y, Boczek NJ, Ferber MJ, Lahner C, Elliott S, Ruan Y, Mignot C, Keren B, Xie H, Wang X, Popp B, Zweier C, Piard J, Coubes C, Mau-Them FT, Safraou H, Innes AM, Gauthier J, Michaud JL, Koboldt DC, Sylvie O, Willems M, Tan WH, Cogne B, Rieubland C, Braun D, McLean SD, Platzer K, Zacher P, Oppermann H, Evenepoel L, Blanc P, El Khattabi L, Haque N, Dsouza NR, Zimmermann MT, Urrutia R, Klee EW, Shen Y, Du H, Rappaport L, Liu CM, Chen X.) Am J Hum Genet. 2024 Nov 07;111(11):2392-2410 PMID: 39419027 PMCID: PMC11568763 SCOPUS ID: 2-s2.0-85207372821 10/18/2024
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(Hall WA, Mathison AJ, DeVoe E, Tschannen M, Wendt-Andrae J, Straza M, Awan M, Puckett LL, Lawton CAF, Schultz C, Urrutia R, Kerns S, Torres-Roca JF, Li XA, Erickson B, Nevalainen MT, Zimmermann MT, Paulson E.) Int J Radiat Oncol Biol Phys. 2024 Oct 01;120(2):570-578 PMID: 38819340 SCOPUS ID: 2-s2.0-85194948255 05/31/2024
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(Pollin G, Lomberk GA, Mathison AJ, Zimmermann MT, Urrutia R.) J Gastrointest Oncol. 2024 Aug 31;15(4):1996-2001 PMID: 39279937 PMCID: PMC11399826 09/16/2024
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(Kim J, Zimmermann MT, Mathison AJ, Lomberk G, Urrutia R, Hong JC.) Ann Surg Open. 2024 Jun;5(2):e444 PMID: 38911661 PMCID: PMC11191965 06/24/2024
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(Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA.) Transl Cancer Res. 2024 May 31;13(5):2535-2543 PMID: 38881922 PMCID: PMC11170510 06/17/2024
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(Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC.) J Biol Chem. 2024 Apr;300(4):107146 PMID: 38460939 PMCID: PMC11002309 SCOPUS ID: 2-s2.0-85189184192 03/10/2024
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(Dsouza NR, Cottrell CE, Davies OMT, Tollefson MM, Frieden IJ, Basel D, Urrutia R, Drolet BA, Zimmermann MT.) Life (Basel). 2024 Feb 23;14(3) PMID: 38541623 PMCID: PMC10971029 SCOPUS ID: 2-s2.0-85193266612 03/28/2024
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(Haque N, Wagenknecht JB, Ratnasinghe BD, Zimmermann MT.) PLoS One. 2024;19(11):e0313308 PMID: 39591473 PMCID: PMC11594405 SCOPUS ID: 2-s2.0-85210375728 11/26/2024
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(Dsouza NR, Haque N, Tripathi S, Zimmermann MT.) International Journal of Molecular Sciences. November 2024;25(22) SCOPUS ID: 2-s2.0-85210224251 11/01/2024
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(Pollin G, Lomberk GA, Mathison AJ, Zimmermann MT, Urrutia R.) Journal of Gastrointestinal Oncology. 31 August 2024;15(4):1996-2001 SCOPUS ID: 2-s2.0-85203321495 08/31/2024
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(Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami A, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Hong JC, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G.) Front Genet. 2024;15:1412767 PMID: 38948355 PMCID: PMC11211573 SCOPUS ID: 2-s2.0-85197408751 07/01/2024
Recruitment and Collaboration
- Join us in decoding the human genome to revolutionize medicine! Our lab is at the cutting edge of genetic research, using advanced computational techniques and
innovative biological approaches to unravel the mysteries of human health and disease. We seek passionate collaborators and brilliant minds to help translate genetic data
into life-changing medical breakthroughs. Whether you're a computational or molecular biology expert or data wizard, there's a place for you in our diverse team. Together,
we can pioneer new diagnostic tools, develop mechanistic insights down to the one-of-a-kind genetic variations, and pave the way for truly personalized medicine. Don't just
watch the future of healthcare unfold—help us create it. Join our mission to transform genetic codes into better lives for patients worldwide!
- Our lab's groundbreaking research is reshaping the landscape of modern medicine and genetics. By unraveling the intricate relationships between genes, diseases, and
drug responses, we're paving the way for a future where medical treatment is tailored to each individual's genetic profile. Our discoveries shed light on the molecular
mechanisms behind various cancers and rare genetic disorders, leading to more accurate diagnoses and empowering research towards targeted therapies. The
computational tools we've developed are improving our ability to predict disease risks and treatment outcomes. Our cancer genomics research advances precision oncology
while our findings offer new hope and potential treatment avenues for patients with rare diseases. By bridging the gap between computational analysis and biological
research, we're pushing the boundaries of scientific knowledge and training the next generation of interdisciplinary biomedical researchers. Ultimately, our work aims to
translate complex genetic data into practical, life-changing improvements in patient care, bringing us closer to a future where personalized medicine is the norm.