皇家华人

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Cell Biology, Neurobiology and Anatomy (CBNA)
Olena Isaeva, PhD

Olena Isaeva, PhD

Assistant Professor

Locations

  • Cell Biology, Neurobiology & Anatomy
    BSB4

Contact Information

Education

PhD and DSc, Bogomoletz Institute of Physiology, Kyiv, Ukraine
Postdoctoral, Rutgers New Jersey Medical School, Newark, NJ
Postdoctoral, Geisel School of Medicine at Dartmouth, Hanover, NH

Biography

Dr. Isaeva earned her PhD in Physiology at the Bogomoletz Institute of Physiology in Kyiv Ukraine. She had postdoctoral training in Dr. Natalia Shirokova’s laboratory in Rutgers New Jersey Medical School and the laboratory of Dr. Gregory L Holmes at Geisel School of Medicine at Dartmouth. In 2018 Dr. Isaeva joined the Physiology Department in 皇家华人 as Visiting Assistant Professor. She continues her career in the Department of Cell Biology, Neurobiology, and Anatomy, where she was promoted to Assistant Professor in 2021.

Research Areas of Interest

  • Ion Channels
  • Calcium Signaling
  • Neuropathic Pain
  • Epilepsy research
  • Synaptic Physiology and Plasticity
  • Behavioral Neuroscience

Methodologies and Techniques

  • Single-Channel and Whole-Cell Patch Clamp
  • Field Potential and Synaptic Plasticity
  • EEG in Rodents
  • Microscopy, Confocal
  • Animal Behavior
  • Cell Culture
  • Immunolabeling
  • Auditory Brain Response
  • Transepithelial Current Measurement

Research Areas of Interest

  • Calcium Signaling
  • Epilepsy
  • Hearing Disorders
  • Hippocampus
  • Hypertension
  • Ion Channels
  • Kidney
  • Pain
  • Sensation Disorders

Research Experience

  • Behavior, Animal
  • Electroencephalography
  • Functional Neuroimaging
  • Hearing Tests
  • Patch-Clamp Techniques

Research Interests

Dr. Isaeva has broad expertise in cell biology, biophysics, neuroscience, and renal physiology. Her main research interests are focused on the study of biophysical and pharmacological properties of ion channels in neuronal and epithelial cells. Ion channels play a critical physiological role in the regulation of cellular homeostasis, ion transport, and signal transduction. Moreover, many human diseases are linked to ion channel malfunctions. So, understanding their specific role and complex interaction of ion channels with extra- and intracellular signaling cascades in the development and progression of pathophysiological processes is important for new drug design and efficient therapy. For many years Dr. Isaeva studies were focused on the role of ligand- and voltage-gated ion channels in the cellular and network mechanisms underlying the disturbance of the physiological patterns of neuronal activity in the central nervous system by brain insults or genetic disorders. In Dr. Cheryl Stucky laboratory Dr. Isaeva focuses her studies on the cellular and molecular mechanisms that underlie mechanical sensitization and pain.

Publications

  • (Yang C, Isaeva E, Shimada S, Kurth T, Stumpf M, Zheleznova NN, Staruschenko A, Dash RK, Cowley AW Jr.) Am J Physiol Renal Physiol. 2024 Sep 01;327(3):F435-F449 PMID: 38779754 PMCID: PMC11460535 SCOPUS ID: 2-s2.0-85201902774 05/23/2024

  • (Allison RL, Welby E, Ehlers V, Burand A, Isaeva O, Nieves Torres D, Highland J, Brandow AM, Stucky CL, Ebert AD.) Blood. 2024 May 16;143(20):2037-2052 PMID: 38427938 PMCID: PMC11143522 SCOPUS ID: 2-s2.0-85189689054 03/01/2024

  • (Waltz TB, Chao D, Prodoehl EK, Enders JD, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL.) JCI Insight. 2024 Mar 07;9(8) PMID: 38646936 PMCID: PMC11141882 SCOPUS ID: 2-s2.0-85191335156 04/22/2024

  • (Mikesell AR, Isaeva E, Schulte ML, Menzel AD, Sriram A, Prahl MM, Shin SM, Sadler KE, Yu H, Stucky CL.) bioRxiv. 2023 Dec 13 PMID: 38168305 PMCID: PMC10760029 01/04/2024

  • (Bohovyk R, Khedr S, Levchenko V, Stefanenko M, Semenikhina M, Kravtsova O, Isaeva E, Geurts AM, Klemens CA, Palygin O, Staruschenko A.) Diabetes. 2023 Dec 01;72(12):1795-1808 PMID: 37722138 PMCID: PMC10658073 SCOPUS ID: 2-s2.0-85176576178 09/18/2023

  • (Nikolaienko O, Klymenko M, Isaeva E.) Neurol Res. 2023 Dec;45(12):1152-1160 PMID: 37698124 SCOPUS ID: 2-s2.0-85170670600 09/12/2023

  • (Chulkov EG, Isaeva E, Stucky CL, Marchant JS.) Int J Parasitol. 2023 Jul;53(8):427-434 PMID: 36610555 PMCID: PMC10258140 SCOPUS ID: 2-s2.0-85146298174 01/08/2023

  • (Polat OK, Isaeva E, Sudhini YR, Knott B, Zhu K, Noben M, Suresh Kumar V, Endlich N, Mangos S, Reddy TV, Samelko B, Wei C, Altintas MM, Dryer SE, Sever S, Staruschenko A, Reiser J.) Kidney Int. 2023 Jun;103(6):1056-1062 PMID: 36750145 PMCID: PMC10200725 SCOPUS ID: 2-s2.0-85148731140 02/08/2023

  • (Waltz TB, Chao D, Prodoehl EK, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL.) bioRxiv. 2023 May 28 PMID: 37292928 PMCID: PMC10245981 06/09/2023

  • (Nagree MS, Rybova J, Kleynerman A, Ahrenhoerster CJ, Saville JT, Xu T, Bachochin M, McKillop WM, Lawlor MW, Pshezhetsky AV, Isaeva O, Budde MD, Fuller M, Medin JA.) Commun Biol. 2023 May 25;6(1):560 PMID: 37231125 PMCID: PMC10212955 SCOPUS ID: 2-s2.0-85160222255 05/26/2023

  • (Savotchenko AV, Isaeva EV, Isaev DS.) Biopolymers and Cell. 2023;39(2):146-151 SCOPUS ID: 2-s2.0-85166955495 01/01/2023

  • (Savotchenko AV, Isaeva EV, Isaev DS.) Fiziologichnyi Zhurnal. 2023;69(4):40-44 SCOPUS ID: 2-s2.0-85169801582 01/01/2023

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