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Cell Biology, Neurobiology and Anatomy (CBNA)
Jonathan-Marchant

Jonathan S. Marchant, MA, PhD

Marcus Professor & Chair

Locations

  • Cell Biology, Neurobiology & Anatomy, BSB4

Contact Information

Education

PhD, Pharmacology, Cambridge University
Postdoctoral, Neurobiology & Behavior, UC Irvine, CA

Biography

Dr. Marchant received his PhD in Pharmacology from the University of Cambridge in the laboratory of Colin Taylor, and then performed post-doctoral training as a Wellcome Trust Training Fellow in Ian Parker’s laboratory in the Department of Neurobiology and Behavior at the University of California-Irvine. He was a Faculty Member in the Department of Pharmacology at the University of Minnesota from 2002-2017, until joining MCW as the Marcus Chair of Cell Biology, Neurobiology and Anatomy in 2017.

In a groundbreaking study, Dr. Marchant and his team identified a new class of compounds called benzamidoquinazolinones (BZQs) that show promise as broad-spectrum treatments for trematode infections in humans.

Read the full story

Research Areas of Interest

  • Antiparasitic Agents
  • Calcium Channels
  • Calcium Signaling
  • Endoplasmic Reticulum
  • Endosomes
  • Ion Channels
  • Lysosomes
  • Schistosomiasis

Research Experience

  • Fluorescent Dyes
  • Gene Silencing
  • High-Throughput Screening Assays
  • Membrane Proteins
  • Microinjections
  • Microscopy, Confocal
  • Planarians
  • RNA Interference
  • Signal Transduction

Research Interests

We are interested in the how cells respond to stimulation. Our focus is on signal transduction through Ca2+ signaling. Indeed, it is hard to think of any cellular process that is not regulated by Ca2+. Ca2+ signals can result from activation of intracellular Ca2+ channels and dysfunction of these same Ca2+ channels are involved in neurodegenerative disease and cancer. To appreciate how cell functions are controlled by Ca2+ signals, and how pathological cues subvert their function, we must understand how the distribution and the regulatory properties of intracellular Ca2+ channels control the genesis of Ca2+ signals.

Publications

  • (Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS.) Nat Struct Mol Biol. 2024 Sep;31(9):1386-1393 PMID: 38714890 SCOPUS ID: 2-s2.0-85192232257 05/08/2024

  • (Marchant JS.) PLoS Negl Trop Dis. 2024 Feb;18(2):e0011929 PMID: 38358948 PMCID: PMC10868838 SCOPUS ID: 2-s2.0-85185235832 02/15/2024

  • (Park SK, Sprague DJ, Rohr CM, Chulkov EG, Petrow I, Kumar S, Marchant JS.) J Biol Chem. 2024 Jan;300(1):105528 PMID: 38043794 PMCID: PMC10788528 SCOPUS ID: 2-s2.0-85180267343 12/04/2023

  • (Gunaratne GS, Kumar S, Lin-Moshier Y, Slama JT, Brailoiu E, Patel S, Walseth TF, Marchant JS.) J Biol Chem. 2023 Dec;299(12):105378 PMID: 37866635 PMCID: PMC10685313 SCOPUS ID: 2-s2.0-85176734898 10/23/2023

  • (Sprague DJ, Kaethner M, Park SK, Rohr CM, Harris JL, Maillard D, Spangenberg T, Lundström-Stadelmann B, Marchant JS.) ACS Med Chem Lett. 2023 Nov 09;14(11):1537-1543 PMID: 37970586 PMCID: PMC10641913 SCOPUS ID: 2-s2.0-85177728490 11/16/2023

  • (Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS.) bioRxiv. 2023 Sep 22 PMID: 37790347 PMCID: PMC10542552 10/04/2023

  • (Friedrich L, Park SK, Ballard P, Ho Baeurle TH, Maillard D, Bödding M, Keiser J, Marchant JS, Spangenberg T.) ChemMedChem. 2023 Sep 15;18(18):e202300140 PMID: 37272317 PMCID: PMC10530395 SCOPUS ID: 2-s2.0-85161895130 06/05/2023

  • (Gunaratne GS, Brailoiu E, Kumar S, Yuan Y, Slama JT, Walseth TF, Patel S, Marchant JS.) Sci Signal. 2023 Aug 22;16(799):eadg0485 PMID: 37607218 PMCID: PMC10639087 SCOPUS ID: 2-s2.0-85168792524 08/22/2023

  • (Saito R, Mu Q, Yuan Y, Rubio-Alarcón M, Eznarriaga M, Zhao P, Gunaratne G, Kumar S, Keller M, Bracher F, Grimm C, Brailoiu E, Marchant JS, Rahman T, Patel S.) Sci Signal. 2023 Aug 22;16(799):eadg0661 PMID: 37607219 PMCID: PMC10639088 SCOPUS ID: 2-s2.0-85168781300 08/22/2023

  • (Chulkov EG, Isaeva E, Stucky CL, Marchant JS.) Int J Parasitol. 2023 Jul;53(8):427-434 PMID: 36610555 PMCID: PMC10258140 SCOPUS ID: 2-s2.0-85146298174 01/08/2023

  • (Chulkov EG, Palygin O, Yahya NA, Park SK, Marchant JS.) Int J Parasitol. 2023 Jul;53(8):415-425 PMID: 36610556 PMCID: PMC10258134 SCOPUS ID: 2-s2.0-85146083227 01/08/2023

  • (Yahya NA, Lanham JK, Sprague DJ, Palygin O, McCorvy JD, Marchant JS.) Am J Physiol Cell Physiol. 2023 Feb 01;324(2):C573-C587 PMID: 36622066 PMCID: PMC9942900 SCOPUS ID: 2-s2.0-85148113561 01/10/2023

Publications of from the

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