皇家华人

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Biophysics
Fabrizio Marinelli, PhD

Fabrizio Marinelli, PhD

Assistant Professor

Locations

  • Biophysics
  • MFRC 3040G

Contact Information

Education

Postdoctoral Fellow, Max Planck Institute of Biophysics, Department of Theoretical Molecular Biophysics, Frankfurt am Main, Germany, 2009-2013
Visiting Fellow, NHLBI, NIH, Theoretical Molecular Biophysics Section, Bethesda, MD, 2013-2046
PhD in Statistical and Biological Physics, International School for Advanced Studies, Trieste, Italy, 2009
MS in Chemistry, La Sapienza University, Rome, Italy, 2005

Biography

I earned my PhD in statistical and biological physics from the International School for Advanced Studies in Trieste, Italy, where I developed innovative molecular simulation techniques to explore protein structure, dynamics, and function. My postdoctoral work at the Max Planck Institute of Biophysics in Frankfurt, Germany, and later at the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH), focused on advancing computational methods to study transport across biological membranes.

In 2016, I was appointed staff scientist at NHLBI/NIH, where I led an interdisciplinary research program aimed at understanding the mechanisms of key membrane transport proteins and developing computational approaches to integrate simulations with experimental data, such as EPR/DEER and HDX-MS. During my time at the NIH, I was also actively involved in teaching and mentoring. In July 2024, I joined the 皇家华人 as assistant professor of biophysics and data science, and have been approved for promotion to associate professor effective July 2025. I also hold an adjunct senior investigator position at the Versiti Blood Research Institute. My current research at MCW focuses on developing computational models to tackle key biological and medical problems.

Research Interests

My lab investigates how cells function at the molecular level, with a focus on membrane transport, signaling, and morphological changes. This research relies on state-of-the-art and advanced molecular simulation techniques, grounded in statistical mechanics and machine learning. A core aspect of our research is the development of novel methodologies to integrate molecular simulations with diverse experimental data sources, such as NMR, EPR, FRET, cryo-EM, and HDX-MS. Our team also pioneers enhanced sampling methods and new approaches for rationalizing simulation and experimental data. This highly interdisciplinary work often involves close collaboration with leading experimental labs. By bridging structure and dynamics, our research aims to advance our understanding of proteins and cellular membranes across both molecular and supramolecular scales, with the goal of discovering new therapies for diseases, particularly in the areas of infectious diseases, drug resistance, and cancer.

Lab Members
Emmanuel Barbosa, Postdoctoral Researcher

Marinelli_Academic Profile Content_Scheme

Publications

  • (Marinelli F, Faraldo-Gómez JD.) Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2318009121 PMID: 38588414 PMCID: PMC11032461 SCOPUS ID: 2-s2.0-85190324798 04/08/2024

  • (Fiorin G, Marinelli F, Forrest LR, Chen H, Chipot C, Kohlmeyer A, Santuz H, and Hénin J.) J Phys Chem B. 11/04/2024

  • (Oh S, Marinelli F, Zhou W, Lee J, Choi HJ, Kim M, Faraldo-Gómez JD, Hite RK.) Elife. 2022 May 24;11 PMID: 35608336 PMCID: PMC9129878 SCOPUS ID: 2-s2.0-85130675029 05/25/2022

  • (Marinelli F, Faraldo-Gómez JD.) J Chem Theory Comput. 2021 Nov 09;17(11):6775-6788 PMID: 34669402 SCOPUS ID: 2-s2.0-85118805062 10/21/2021

  • (Lee PS, Bradshaw RT, Marinelli F, Kihn K, Smith A, Wintrode PL, Deredge DJ, Faraldo-Gómez JD, Forrest LR.) Living J Comput Mol Sci. 2021;3(1) PMID: 36644498 PMCID: PMC9835200 01/01/2021

  • (Bradshaw RT, Marinelli F, Faraldo-Gómez JD, Forrest LR.) Biophys J. 2020 Apr 07;118(7):1649-1664 PMID: 32105651 PMCID: PMC7136279 SCOPUS ID: 2-s2.0-85080084845 02/28/2020

  • (Fiorin G, Marinelli F, Faraldo-Gómez JD.) J Comput Chem. 2020 Feb 15;41(5):449-459 PMID: 31602694 PMCID: PMC8388148 SCOPUS ID: 2-s2.0-85074051447 10/12/2019

  • (PLUMED consortium.) Nat Methods. 2019 Aug;16(8):670-673 PMID: 31363226 SCOPUS ID: 2-s2.0-85069961147 08/01/2019

  • (Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gómez JD, Hattori M, Swartz KJ.) Elife. 2019 Jun 24;8 PMID: 31232692 PMCID: PMC6590987 SCOPUS ID: 2-s2.0-85071880082 06/25/2019

  • (Marinelli F, Fiorin G.) Structure. 2019 Feb 05;27(2):359-370.e12 PMID: 30528595 PMCID: PMC6860373 SCOPUS ID: 2-s2.0-85060735246 12/12/2018

  • (Hustedt EJ, Marinelli F, Stein RA, Faraldo-Gómez JD, Mchaourab HS.) Biophys J. 2018 Oct 02;115(7):1200-1216 PMID: 30197182 PMCID: PMC6170522 SCOPUS ID: 2-s2.0-85052928173 09/11/2018

  • (Shlosman I, Marinelli F, Faraldo-Gómez JD, Mindell JA.) J Gen Physiol. 2018 Jan 02;150(1):51-65 PMID: 29237756 PMCID: PMC5749117 SCOPUS ID: 2-s2.0-85039953929 12/15/2017

Publications of from the

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