皇家华人

皇家华人
皇家华人 皇家华人
Research Collaborate Lab Bench
Biochemistry
Gustavo W. Leone, PhD

Gustavo W. Leone, PhD

Professor; Director, MCW Cancer Center; Senior Associate Dean of Cancer Research

Locations

  • CCC C5317

Contact Information

Education

Post-doctoral Training, Duke University Medical Center, 1994-1998
PhD, Virology, University of Calgary, 1994
BS, Biochemistry, University of Calgary, 1988

Biography

Gustavo W. Leone, PhD, started in his role as Director of the MCW Cancer Center, Senior Associate Dean of Cancer Research, and Professor of Biochemistry on April 15, 2020. Prior to his arrival at MCW, Dr. Leone served as the Director of the NCI-designated Hollings Cancer Center at the Medical University of South Carolina from March 2017 to April 2020. Dr. Leone’s past research includes graduate work in biochemical and biophysical approaches to study protein function and virology (reovirus), with a specific emphasis on mechanisms of viral mediated entry into host cells. As a postdoctoral fellow at Duke University, he had the seminal finding linking Cyclin Dependent Kinases to the control of E2F transcription factors and regulation of the cell cycle.

Research Interests

Currently, Dr. Leone has an active research program that utilizes genetic models (cell-based systems, worms, and mice) to study Rb/E2F & PTEN signaling in the context of cell cycle control, endoreduplication, developmental biology and cancer (endometrial, liver, pancreatic, and breast cancers), as well as the genetics and biology of PTEN and the tumor microenvironment. Dr. Leone’s research group has made seminal contributions in two broad areas of research, one in the role of the Rb/E2F pathway in development and cancer, and the other in signaling between cells within the tumor microenvironment.

Publications

  • (Del Bufalo F, De Angelis B, Caruana I, Del Baldo G, De Ioris MA, Serra A, Mastronuzzi A, Cefalo MG, Pagliara D, Amicucci M, Li Pira G, Leone G, Bertaina V, Sinibaldi M, Di Cecca S, Guercio M, Abbaszadeh Z, Iaffaldano L, Gunetti M, Iacovelli S, Bugianesi R, Macchia S, Algeri M, Merli P, Galaverna F, Abbas R, Garganese MC, Villani MF, Colafati GS, Bonetti F, Rabusin M, Perruccio K, Folsi V, Quintarelli C, Locatelli F, Precision Medicine Team鈥揑RCCS Ospedale Pediatrico Bambino Gesù.) N Engl J Med. 2023 Apr 06;388(14):1284-1295 PMID: 37018492 04/06/2023

  • (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P.) Cell Rep. 2023 Mar 28;42(3):112228 PMID: 36884347 PMCID: PMC10233815 SCOPUS ID: 2-s2.0-85149682952 03/09/2023

  • (Yu Z, Zhang L, Cattaneo P, Guimarães-Camboa N, Fang X, Gu Y, Peterson KL, Bogomolovas J, Cuitino C, Leone GW, Chen J, Evans SM.) Circulation. 2023 Jan 10;147(2):183-186 PMID: 36622904 PMCID: PMC9988404 SCOPUS ID: 2-s2.0-85145688465 01/10/2023

  • (Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G.) Nat Commun. 2023 Jan 03;14(1):1 PMID: 36596776 PMCID: PMC9810714 SCOPUS ID: 2-s2.0-85145429848 01/04/2023

  • (Fong BC, Chakroun I, Iqbal MA, Paul S, Bastasic J, O'Neil D, Yakubovich E, Bejjani AT, Ahmadi N, Carter A, Clark A, Leone G, Park DS, Ghanem N, Vandenbosch R, Slack RS.) Cell Rep. 2022 Nov 01;41(5):111578 PMID: 36323247 SCOPUS ID: 2-s2.0-85140871739 11/03/2022

  • (Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE 3rd, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC.) Life Sci Alliance. 2022 Nov;5(11) PMID: 35803738 PMCID: PMC9270499 SCOPUS ID: 2-s2.0-85134426331 07/09/2022

  • (Corchado-Sonera M, Rambani K, Navarro K, Kladney R, Dowdle J, Leone G, Chamberlin HM.) G3 (Bethesda). 2022 Sep 30;12(10) PMID: 35929788 PMCID: PMC9526067 SCOPUS ID: 2-s2.0-85139433642 08/06/2022

  • (Wu J, Liu X, Reeser JAW, Trimboli AJ, Pécot T, Sizemore GM, Naidu SK, Fernandez SA, Yu L, Hallett M, Park M, Leone GW, Hildreth BE, Ostrowski MC.) Mol Cancer Res. 2022 Aug 05;20(8):1233-1246 PMID: 35533313 PMCID: PMC9357052 SCOPUS ID: 2-s2.0-85135596986 05/10/2022

  • (Ochoa-Rios S, O'Connor IP, Kent LN, Clouse JM, Hadjiyannis Y, Koivisto C, Pecot T, Angel PM, Drake RR, Leone G, Mehta AS, Rockey DC.) Mol Cell Proteomics. 2022 May;21(5):100225 PMID: 35331917 PMCID: PMC9092512 SCOPUS ID: 2-s2.0-85130862256 03/26/2022

  • (Yoshida A, Phillips-Mason P, Tarallo V, Avril S, Koivisto C, Leone G, Diehl JA.) Oncogene. 2022 Apr;41(15):2187-2195 PMID: 35210557 PMCID: PMC10056880 SCOPUS ID: 2-s2.0-85125132416 02/26/2022

  • (Pécot T, Cuitiño MC, Johnson RH, Timmers C, Leone G.) PLoS Comput Biol. 2022 Mar;18(3):e1009949 PMID: 35286300 PMCID: PMC8947602 SCOPUS ID: 2-s2.0-85126910772 03/15/2022

  • (Han L, Seward C, Leone G, Ostrowski MC.) Adv Cancer Res. 2022;154:169-201 PMID: 35459469 SCOPUS ID: 2-s2.0-85127356799 04/24/2022

Publications of from the