皇家华人

皇家华人
皇家华人 皇家华人
what
Anesthesiology
Dorothee-Weihrauch

Dorothee Weihrauch, DVM, PhD

Professor

Contact Information

Education

DVM, Justus Liebig University, Giessen, Germany, 1989
PhD, Max-Planck Institute for Experimental Cardiology, Bad Nauheim, Germany, 1993
Postdoctoral training, Cardiovascular Physiology, Texas A&M, College Station, TX, 1995
Postdoctoral training, Cardiovascular Physiology, 皇家华人, 1996

Research Interests

  1. Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC Study
  2. Function of myeloperoxidase (MPO) in collateral growth in a model of diabetes
  3. Understanding preeclampsia: Search for novel therapeutic modalities
  4. Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis

Publications

  • (Weihrauch D, Keszler A, Broeckel G, Aranda E, Lindemer B, Lohr NL.) Photochem Photobiol Sci. 2024 Feb;23(2):355-364 PMID: 38277065 PMCID: PMC10917865 SCOPUS ID: 2-s2.0-85183148947 01/26/2024

  • (Roth E, Linehan A, Weihrauch D, Stucky C, Hogan Q, Hoben G.) Pain. 2023 Feb 01;164(2):316-324 PMID: 35639439 SCOPUS ID: 2-s2.0-85143752837 06/01/2022

  • (Keszler A, Lindemer B, Broeckel G, Weihrauch D, Gao Y, Lohr NL.) Front Physiol. 2022;13:880158 PMID: 35586710 PMCID: PMC9108481 05/20/2022

  • (Griffin J, Krolikowski JG, Kounga K, Struve J, Keszler A, Lindemer B, Bordas M, Broeckel G, Lohr NL, Weihrauch D.) J Pregnancy. 2022;2022:3922368 PMID: 35494491 PMCID: PMC9045993 SCOPUS ID: 2-s2.0-85129568653 05/03/2022

  • (Compton T, Poellinger N, Struve J, Krolikowski JG, Ninomiya JT, Weihrauch D.) J Vis Exp. 2021 Dec 30(178) PMID: 35037662 SCOPUS ID: 2-s2.0-85123654791 01/18/2022

  • (Weihrauch D, Keszler A, Lindemer B, Krolikowski J, Lohr NL.) J Photochem Photobiol B. 2021 Jul;220:112212 PMID: 34049180 PMCID: PMC8240139 SCOPUS ID: 2-s2.0-85107807187 05/29/2021

  • (Weihrauch D, Shumpert SD, Larson ME, McVey N, Krolikowski JG, Bamkole O, Riess ML.) JPEN J Parenter Enteral Nutr. 2021 Feb;45(2):295-302 PMID: 32291784 PMCID: PMC8480443 SCOPUS ID: 2-s2.0-85083448695 04/16/2020

  • (Gebremendhin D, Lindemer B, Weihrauch D, Harder DR, Lohr NL.) PLoS One. 2021;16(10):e0257896 PMID: 34610026 PMCID: PMC8491904 SCOPUS ID: 2-s2.0-85116591248 10/06/2021

  • (D'Souza A, Szabo A, Flynn KE, Dhakal B, Chhabra S, Pasquini MC, Weihrauch D, Hari PN.) EClinicalMedicine. 2020 Jun;23:100361 PMID: 32529175 PMCID: PMC7280748 06/13/2020

  • (Riess ML, Elorbany R, Weihrauch D, Stowe DF, Camara AKS.) Cells. 2020 Jan 20;9(1) PMID: 31968546 PMCID: PMC7017211 SCOPUS ID: 2-s2.0-85099486696 01/24/2020

  • (Weihrauch D, Martin DP, Jones D, Krolikowski J, Struve J, Naylor S, Pritchard KA Jr.) Diab Vasc Dis Res. 2020;17(3):1479164120907971 PMID: 32223319 PMCID: PMC7510377 SCOPUS ID: 2-s2.0-85082634881 04/01/2020

  • (Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL.) Free Radic Biol Med. 2019 Feb 01;131:443 PMID: 30581102 SCOPUS ID: 2-s2.0-85058702220 12/26/2018

Publications of from the

Brief Research Summaries

Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC Study

This study represents one of the largest collections of existing hiPSC cell lines from an epidemiological study. As part of this project, we study the role and interaction of the cardiac matrix with expression changes on human iPSC-CMs.

Function of myeloperoxidase (MPO) in collateral growth in a model of diabetes

The function of MPO in the development of collateral growth is unknown. We are focusing on the role of MPO in a well-established model of diabetes, the db/db mouse.

Understanding preeclampsia: Novel therapeutic modalities

This study focuses on a better understanding of this multifactorial disease which affects 8% of all pregnant women and has great impact on their cardiovascular health. Our findings point us to different pathways for early and late onset of preeclampsia. We are currently pursuing the benefits of near infrared light (670nm) in this project.

Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis

We have found nitric oxide (NO) precursors in blood and tissues which are stimulated by 670 nm light energy (R/NIR) to release NO and produce a stable NO bound vasodilator. The goal is to assess the impact of these iron and thiol based NO precursors in a chronic model of angiogenesis-rat hindlimb ischemia.